Powerball is a multi-state lottery game in the United States.
Powerball may also refer to:
Lotteries
- Powerball (Australia), a lottery operated in Australia
- The Powerball game of Lotto New Zealand
- The PowerBall game in the South African National Lottery
Arts, entertainment, and media
- Powerball (video game), a game for the Sega Genesis
- Powerball, an event on the sports competition show American Gladiators
- Powerball, a mode in the strategy shooting game GunBound
- Powerballin', a 2004 Chingy album
Other uses
- Powerball, a brand of gyroscopic exercise tool
- Powerballing, alternate name for the drug speedball
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