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Premnaspirodiene oxygenase (EC 1.14.13.121, HPO, Hyoscymus muticus premnaspirodiene oxygenase) is an enzyme with systematic name (-)-vetispiradiene,NADPH:oxygen 2alpha-oxidoreductase. This enzyme catalyses the following chemical reaction

(-)-vetispiradiene + 2 NADPH + 2 H + 2 O₂ ${\displaystyle \rightleftharpoons }$ solavetivone + 2 NADP + 3 H₂O (overall reaction)

(1a) (-)-vetispiradiene + NADPH + H + O₂ ${\displaystyle \rightleftharpoons }$ solavetivol + NADP + H₂O

(1b) solavetivol + NADPH + H + O₂ ${\displaystyle \rightleftharpoons }$ solavetivone + NADP + 2 H₂O

Premnaspirodiene oxygenase heme-thiolate protein (P-450).

References

1. Takahashi S, Yeo YS, Zhao Y, O'Maille PE, Greenhagen BT, Noel JP, Coates RM, Chappell J (October 2007). "Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio- and stereo-specific hydroxylations of diverse sesquiterpene substrates". The Journal of Biological Chemistry. 282 (43): 31744–54. doi:10.1074/jbc.M703378200. PMC 2695360. PMID 17715131.

External links

• Premnaspirodiene+oxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Biology

• EC 1.14.13