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Trade names | Adipotide |
Other names | Prohibitin-TP01; TP01 |
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Prohibitin-targeting peptide 1 (also known as prohibitin-TP01 and TP01; trade name Adipotide) is a peptidomimetic with sequence CKGGRAKDC-GG-D(KLAKLAK)2. It is an experimental proapoptotic drug that has been shown to cause rapid weight loss in mice and rhesus monkeys. Its mechanism of action is to target specific blood vessels supplying adipose tissue with blood, cause the vessels to shrink and the fat cells fed by those vessels to undergo apoptosis. TP01 is designed to bind to two receptors, ANXA2 and prohibitin, that are specific to blood vessels supplying white adipose tissue.
As of 2019, clinical development has been discontinued.
References
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- Staquicini FI, Cardó-Vila M, Kolonin MG, Trepel M, Edwards JK, Nunes DN, et al. (November 2011). "Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients". Proceedings of the National Academy of Sciences of the United States of America. 108 (46): 18637–42. Bibcode:2011PNAS..10818637S. doi:10.1073/pnas.1114503108. PMC 3219136. PMID 22049339.
- "Prohibitin targeting peptide 1". Adis Insight. Springer Nature Switzerland AG.