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Prokineticin 1
Prokineticin 1
Identifiers
Symbol	PROK1
NCBI gene	84432
HGNC	18454
OMIM	606233
RefSeq	NM_032414
UniProt	P58294
Other data
Locus	Chr. 1 p21
Search for Structures Swiss-model Domains InterPro

Prokineticin is a secreted protein that potently contracts gastrointestinal smooth muscle.

Recently, prokineticins have been recognized in humans and other vertebrates. They are thought to be involved in several important physiological processes like neurogenesis, tissue development, angiogenesis, and nociception. Other important physiological roles the Bv8/Prokineticins (PKs) are involved in may include cancer, reproduction, and regulating physiological functions that influence circadian rhythms like hormone secretion, ingestive behaviors, and the sleep/wake cycle.

Mutations in the PROK2 (also known as KAL4) gene have been implicated in hypogonadotropic hypogonadism and gynecomastia.

See also

• Prokineticin receptor

References

1. "RCSB Protein Data Bank - Structure Summary for 2KRA - Solution structure of Bv8".
2. Li M, Bullock CM, Knauer DJ, Ehlert FJ, Zhou QY (2001). "Identification of two prokineticin cDNAs: recombinant proteins potently contract gastrointestinal smooth muscle". Mol. Pharmacol. 59 (4): 692–8. doi:10.1124/mol.59.4.692. PMID 11259612. S2CID 1597745.
3. ^ Morales RA, Daly NL, Vetter I, et al. (September 2010). "Chemical synthesis and structure of the prokineticin Bv8". ChemBioChem. 11 (13): 1882–8. doi:10.1002/cbic.201000330. PMID 20677202. S2CID 32535956.
4. Liu B, Qiao L, Liu K, Piccinni-Ash TJ, Chen ZF. Molecular and neural basis of pleasant touch sensation. Science 2022; 376(6592):483. doi:10.1126/science.abn2479
5. Negri L, Lattanzi R, Giannini E, Melchiorri P (September 2007). "Bv8/Prokineticin proteins and their receptors". Life Sci. 81 (14): 1103–16. doi:10.1016/j.lfs.2007.08.011. PMID 17881008.
6. Narula, Harmeet S.; Carlson, Harold E. (2014). "Gynaecomastia—pathophysiology, diagnosis and treatment". Nature Reviews Endocrinology. 10 (11): 684–698. doi:10.1038/nrendo.2014.139. ISSN 1759-5029. PMID 25112235. S2CID 40159424.

External links

• PROK1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• PROK2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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