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In enzymology, a protein-glutamine glutaminase (EC 3.5.1.44) is an enzyme that catalyzes the chemical reaction

protein L-glutamine + H₂O ${\displaystyle \rightleftharpoons }$ protein L-glutamate + NH₃

Thus, the two substrates of this enzyme are protein L-glutamine and H₂O, whereas its two products are protein L-glutamate and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is protein-L-glutamine amidohydrolase. Other names in common use include peptidoglutaminase II, glutaminyl-peptide glutaminase, destabilase, and peptidylglutaminase II.

References

• Kikuchi M, Hayashida H, Nakano E, Sakaguchi K (1971). "Peptidoglutaminase. Enzymes for selective deamidation of gamma-amide of peptide-bound glutamine". Biochemistry. 10 (7): 1222–9. doi:10.1021/bi00783a019. PMID 4928623.

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