Somatrem - Misplaced Pages

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Pharmaceutical compound

Somatrem
Clinical data
Trade names	Protropin
AHFS/Drugs.com	Micromedex Detailed Consumer Information
ATC code	H01AC02 (WHO)
Identifiers
CAS Number	82030-87-3
DrugBank	DB09098
ChemSpider	none
UNII	CU8D464EDW
KEGG	D05884
ChEMBL	ChEMBL1201620
Chemical and physical data
Formula	C₉₉₅H₁₅₃₇N₂₆₃O₃₀₁S₈
Molar mass	22256.26 g·mol
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Somatrem, sold under the brand name Protropin, is an analogue of growth hormone (GH).

Overview

Somatrem is a recombinant human growth hormone used for the treatment of short stature due to decreased or absent secretion of endogenous growth hormone.

Somatrem was first marketed under the brand name Protropin by Genentech in 1985. It differs from endogenous growth hormone by the addition of an extra methionine at the N-terminus.

Somatrem has largely been replaced by somatropin, marketed by several companies including by Genentech as the brand Nutropin.

References

Flodh H (1987). "Present situation worldwide regarding the use and clinical experience of Somatonorm (somatrem)". Acta Paediatrica Scandinavica. Supplement. 331: 1–4. doi:10.1111/j.1651-2227.1987.tb17089.x. PMID 3300150. S2CID 20410776.
"Genentech: Press Releases - Friday, Oct 18, 1985". www.gene.com.
Growth hormone therapy#cite note-32

External links

"Somatrem". Drug Information Portal.
HyperGH 14x Growth Hormone Info.

v t e GH/IGF-1 axis signaling modulators
GH (somatotropin)	Agonists: Albusomatropin Bovine somatotropin Efpegsomatropin Eftansomatropin alfa Growth hormone Human placental lactogen Lonapegsomatropin Placental growth hormone (growth hormone variant) Somagrebove Somapacitan Somatosalm Somatotropin Somatropin pegol Somatrem Sometribove Somatrogon (MOD-4023; hGH-CTP) Somavaratan Somavubove Somidobove Antagonists: G120K-hGH Pegvisomant Antisense oligonucleotides: Atesidorsen Binding proteins: GHBPTooltip Growth hormone-binding protein
GHIH (somatostatin)	Agonists: BIM-23052 CH-275 Cortistatin-14 Depreotide Edotreotide Ilatreotide L-803,087 L-817,818 Lanreotide NNC 26-9100 Octreotate Octreotide Pasireotide Pentetreotide RC-160 Seglitide Somatostatin (GHIH) Somatostatin (1-28) SRIF-14 SRIF-28 TT-232 Vapreotide Veldoreotide Antagonists: BIM-23056 Cyclosomatostatin CYN-154806 Satoreotide
GHRH (somatocrinin)	Agonists: Peptide: ALRN-5281 CJC-1295 Dumorelin GHRH Modified GRF (1-29) Rismorelin Sermorelin Somatorelin Tesamorelin Antagonists: MZ-5-156
GHS (ghrelin)	Agonists: Peptide: Alexamorelin Cortistatin-14 EP-51216 Examorelin (hexarelin) Ghrelin GHRP-1 GHRP-3 GHRP-4 GHRP-5 GHRP-6 Ipamorelin Lenomorelin Livoletide LY-444711 Pralmorelin (GHRP-2) Relamorelin Tabimorelin Ulimorelin; Non-peptide: Adenosine Anamorelin Capromorelin CP-464709 Ibutamoren (MK-677) L-692,585 Macimorelin SM-130686; Unsorted: LY-426410 LY-444711 Antagonists: A-778193 Cortistatin-8 (D-Lys³)-GHRP-6 JMV2959 YIL-781
IGF-1 (somatomedin)	See here instead.

Hypothalamic-pituitary hormones and analogues (H01)

Hypothalamus

Gonadotropin-releasing hormone (GnRH)	Agonists: Gonadorelin Nafarelin Histrelin Antagonists: Cetrorelix Elagolix Ganirelix Relugolix (+estradiol/norethisterone acetate)
Somatostatin	Agonists: Lanreotide Octreotide Pasireotide Vapreotide

Anterior pituitary

Adrenocorticotropic hormone (ACTH)

Growth hormone (GH)

Agonists: Insulin-like growth factor 1 (IGF-1) (Mecasermin/Mecasermin rinfabate)
Somapacitan
Somatrem
Somatrogon

Antagonists: Pegvisomant

Thyroid-stimulating hormone (TSH)

Agonists: Thyrotropin

Posterior pituitary

Oxytocin	Agonists: Argiprestocin Carbetocin Cargutocin Demoxytocin Nacartocin Antagonists: Atosiban Barusiban
Vasopressin	Agonists: Argipressin Desmopressin Felypressin Lypressin Ornipressin Terlipressin Antagonists: Conivaptan Demeclocycline Lixivaptan Mozavaptan Nelivaptan Relcovaptan Satavaptan Tolvaptan

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