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Psammoma body

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(Redirected from Psammoma bodies) Microscopic nodule of calcium in the body
Micrograph of psammoma body in the centre of the field in a meningioma of brain. H&E stain.

A psammoma body is a round collection of calcium, seen microscopically. The term is derived from Greek άμμος (ámmos) 'sand'.

Cause

Psammoma bodies are associated with the papillary (nipple-like) histomorphology and are thought to arise from,

  1. Infarction and calcification of papillae tips.
  2. Calcification of intralymphatic tumor thrombi.

Association with lesions

Psammoma bodies are commonly seen in certain tumors such as:

Benign lesions

Micrograph of a psammomatous melanotic schwannoma with a psammoma body, as may be seen in Carney complex. H&E stain.

Psammoma bodies may be seen in:

Appearance

Psammoma bodies usually have a laminar appearance, are circular, acellular and basophilic.

References

  1. Johannessen JV, Sobrinho-Simões M (September 1980). "The origin and significance of thyroid psammoma bodies". Lab. Invest. 43 (3): 287–96. PMID 7401638.
  2. Chapter 20 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K; Fausto, Nelson (2007). Robbins Basic Pathology. Philadelphia: Saunders. ISBN 978-1-4160-2973-1. 8th edition.
  3. "Renal Cell Carcinoma". The Lecturio Medical Concept Library. Retrieved 1 October 2021.
  4. Ovarian papillary serous cystadenocarcinoma at WebPath, The Internet Pathology Laboratory for Medical Education at Mercer University School of Medicine. Retrieved July 2011
  5. "Brain Stem & Posterior Fossa". Archived from the original on 2000-03-01.
  6. Lewis RB (2010). "Pancreatic Endocrine Tumors: Radiologic-Clinicopathologic Correlation". RadioGraphics. 30 (6): 1445–1464. doi:10.1148/rg.306105523. PMID 21071369.
  7. Robbin's Pathology, Eight Ed
  8. "Glucagonoma". The Lecturio Medical Concept Library. Retrieved 1 October 2021.
  9. Emoto K, Eguchi T, Tan KS, Takahashi Y, Aly RG, Rekhtman N, Travis WD, Adusumilli PS (2019). "Expansion of the Concept of Micropapillary Adenocarcinoma to Include a Newly Recognized Filigree Pattern as Well as the Classical Pattern Based on 1468 Stage I Lung Adenocarcinomas". J Thorac Oncol. 14 (11): 1948–1961. doi:10.1016/j.jtho.2019.07.008. PMC 8785415. PMID 31352072.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  10. Hallman KB, Nahhas WA, Connelly PJ (September 1991). "Endosalpingiosis as a source of psammoma bodies in a Papanicolaou smear. A case report". J Reprod Med. 36 (9): 675–8. PMID 1774734.
  11. Rapini, Ronald. Practical Dermatopathology. Elsevier Mosby, 2005, p. 10.

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