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Pseudouridylate synthase

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pseudouridylate synthase
Identifiers
EC no.4.2.1.70
CAS no.9023-35-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

The enzyme pseudouridylate synthase (EC 4.2.1.70) catalyzes the chemical reaction

uracil + D-ribose 5-phosphate {\displaystyle \rightleftharpoons } pseudouridine 5′-phosphate + H2O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is uracil hydro-lyase (adding D-ribose 5-phosphate pseudouridine-5′-phosphate-forming). Other names in common use include pseudouridylic acid synthetase, pseudouridine monophosphate synthetase, 5-ribosyluracil 5-phosphate synthetase, pseudouridylate synthetase, upsilonUMP synthetase, and uracil hydro-lyase (adding D-ribose 5-phosphate). This enzyme participates in pyrimidine metabolism.

Structural studies

As of late 2007, 22 structures have been solved for this class of enzymes, with PDB accession codes 1DJ0, 1K8W, 1KSK, 1KSL, 1KSV, 1PRZ, 1QYU, 1R3E, 1R3F, 1SB7, 1SGV, 1SI7, 1SZW, 1V9F, 1V9K, 1VIO, 1XPI, 1Z2Z, 1ZE1, 1ZE2, 1ZL3, and 2I82.

References

Carbon–oxygen lyases (EC 4.2) (primarily dehydratases)
4.2.1: Hydro-Lyases
4.2.2: Acting on polysaccharides
4.2.3: Acting on phosphates
4.2.99: Other
Enzymes
Activity
Regulation
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Kinetics
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