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In enzymology, a psoralen synthase (EC 1.14.13.102) is an enzyme that catalyzes the chemical reaction

(+)-marmesin + NADPH + H + O₂ ${\displaystyle \rightleftharpoons }$ psoralen + NADP + acetone + 2 H₂O

The 4 substrates of this enzyme are (+)-marmesin, NADPH, H, and O₂, whereas its 4 products are psoralen, NADP, acetone, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O₂ as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O₂ with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is (?). This enzyme is also called CYP71AJ1.

References

• Larbat R, Kellner S, Specker S, Hehn A, Gontier E, Hans J, Bourgaud F, Matern U (January 2007). "Molecular cloning and functional characterization of psoralen synthase, the first committed monooxygenase of furanocoumarin biosynthesis" (PDF). The Journal of Biological Chemistry. 282 (1): 542–54. doi:10.1074/jbc.M604762200. PMID 17068340.

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