| Pyrethroid hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.1.88 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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The enzyme pyrethroid hydrolase (EC 3.1.1.88, pyrethroid-hydrolyzing carboxylesterase, pyrethroid-hydrolysing esterase, pyrethroid-hydrolyzing esterase, pyrethroid-selective esterase, pyrethroid-cleaving enzyme, permethrinase, PytH, EstP; systematic name pyrethroid-ester hydrolase) catalyses the reaction
- trans-permethrin + H2O (3-phenoxyphenyl)methanol + (1S,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate
(3-phenoxyphenyl)methanol + (1S,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylateThe enzyme is involved in degradation of pyrethroid pesticides.
References
- Wang BZ, Guo P, Hang BJ, Li L, He J, Li SP (September 2009). "Cloning of a novel pyrethroid-hydrolyzing carboxylesterase gene from Sphingobium sp. strain JZ-1 and characterization of the gene product". Applied and Environmental Microbiology. 75 (17): 5496–500. doi:10.1128/aem.01298-09. PMC 2737939. PMID 19581484.
- Wu PC, Liu YH, Wang ZY, Zhang XY, Li H, Liang WQ, Luo N, Hu JM, Lu JQ, Luan TG, Cao LX (February 2006). "Molecular cloning, purification, and biochemical characterization of a novel pyrethroid-hydrolyzing esterase from Klebsiella sp. strain ZD112". Journal of Agricultural and Food Chemistry. 54 (3): 836–42. doi:10.1021/jf052691u. PMID 16448191.
- Liang WQ, Wang ZY, Li H, Wu PC, Hu JM, Luo N, Cao LX, Liu YH (September 2005). "Purification and characterization of a novel pyrethroid hydrolase from Aspergillus niger ZD11". Journal of Agricultural and Food Chemistry. 53 (19): 7415–20. doi:10.1021/jf051460k. PMID 16159167.
- Stok JE, Huang H, Jones PD, Wheelock CE, Morisseau C, Hammock BD (July 2004). "Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes". The Journal of Biological Chemistry. 279 (28): 29863–9. doi:10.1074/jbc.m403673200. PMID 15123619.
- Maloney SE, Maule A, Smith AR (July 1993). "Purification and preliminary characterization of permethrinase from a pyrethroid-transforming strain of Bacillus cereus". Applied and Environmental Microbiology. 59 (7): 2007–13. PMC 182228. PMID 8357241.
- Guo, P.; Wang, B.; Hang, B.; Li, L.; Ali, W.; He, J.; Li, S. (2009). "Pyrethroid-degrading Sphingobium sp. JZ-2 and the purification and characterization of a novel pyrethroid hydrolase". Int. Biodeter. Biodegrad. 63 (8): 1107–1112. doi:10.1016/j.ibiod.2009.09.008.
External links
- Pyrethroid+hydrolase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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