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RAB11FIP4
Identifiers
Aliases	RAB11FIP4, RAB11-FIP4, RAB11 family interacting protein 4, FIP4-Rab11
External IDs	OMIM: 611999; MGI: 2442920; HomoloGene: 8803; GeneCards: RAB11FIP4; OMA:RAB11FIP4 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q11.2 Start 31,391,675 bp End 31,538,211 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B5|11 46.88 cM Start 79,482,038 bp End 79,588,849 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex left testis right testis corpus callosum C1 segment putamen right frontal lobe postcentral gyrus Brodmann area 46 dorsolateral prefrontal cortex Top expressed in superior colliculus visual cortex dentate gyrus of hippocampal formation granule cell medial dorsal nucleus primary visual cortex primary motor cortex superior frontal gyrus olfactory tubercle piriform cortex medial geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding protein homodimerization activity metal ion binding protein binding Cellular component cytoplasm endosome membrane endocytic vesicle spindle microtubule organizing center recycling endosome membrane midbody perinuclear region of cytoplasm cleavage furrow cytoskeleton cytoplasmic vesicle extracellular space intracellular membrane-bounded organelle centrosome Biological process positive regulation of G1 to G0 transition cytokinesis viral process neural retina development transport endocytic recycling regulation of cytokinesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84440 268451 Ensembl ENSG00000131242 ENSMUSG00000017639 UniProt Q86YS3 Q8BQP8 RefSeq (mRNA) NM_001303542 NM_001346747 NM_001346748 NM_001346749 NM_032932 NM_175543 RefSeq (protein) NP_001290471 NP_001333676 NP_001333677 NP_001333678 NP_116321 NP_780752 Location (UCSC) Chr 17: 31.39 – 31.54 Mb Chr 11: 79.48 – 79.59 Mb PubMed search
Wikidata
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Rab11 family-interacting protein 4 is a protein that in humans is encoded by the RAB11FIP4 gene.

Interactions

RAB11FIP4 has been shown to interact with RAB11A.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000131242 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000017639 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (May 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
6. Jenne DE, Tinschert S, Reimann H, Lasinger W, Thiel G, Hameister H, Kehrer-Sawatzki H (Aug 2001). "Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions". Am J Hum Genet. 69 (3): 516–527. doi:10.1086/323043. PMC 1235482. PMID 11468690.
7. "Entrez Gene: RAB11FIP4 RAB11 family interacting protein 4 (class II)".
8. Wallace, Deborah M E; Lindsay Andrew J; Hendrick Alan G; McCaffrey Mary W (Dec 2002). "Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells". Biochem. Biophys. Res. Commun. 299 (5). United States: 770–779. doi:10.1016/S0006-291X(02)02720-1. ISSN 0006-291X. PMID 12470645.

Further reading

• Jenne DE, Tinschert S, Stegmann E, et al. (2000). "A common set of at least 11 functional genes is lost in the majority of NF1 patients with gross deletions". Genomics. 66 (1): 93–97. doi:10.1006/geno.2000.6179. PMID 10843809.
• Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW (2003). "Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells". Biochem. Biophys. Res. Commun. 299 (5): 770–779. doi:10.1016/S0006-291X(02)02720-1. PMID 12470645.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jenne DE, Tinschert S, Dorschner MO, et al. (2003). "Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse". Genes Chromosomes Cancer. 37 (2): 111–120. doi:10.1002/gcc.10206. PMID 12696059. S2CID 37232718.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Fielding AB, Schonteich E, Matheson J, et al. (2006). "Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis". EMBO J. 24 (19): 3389–3399. doi:10.1038/sj.emboj.7600803. PMC 1276165. PMID 16148947.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–814. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Douglas J, Cilliers D, Coleman K, et al. (2007). "Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth". Nat. Genet. 39 (8): 963–965. doi:10.1038/ng2083. PMID 17632510. S2CID 35797973.

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