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RAB17
Identifiers
Aliases	RAB17, member RAS oncogene family
External IDs	OMIM: 602206; MGI: 104640; HomoloGene: 7502; GeneCards: RAB17; OMA:RAB17 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q37.3 Start 237,574,322 bp End 237,601,614 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 D|1 45.84 cM Start 90,885,855 bp End 90,897,383 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver renal medulla body of pancreas left lobe of thyroid gland right lobe of thyroid gland human kidney mucosa of transverse colon right uterine tube mucosa of ileum jejunal mucosa Top expressed in submandibular gland Paneth cell jejunum medullary collecting duct ileum vestibular membrane of cochlear duct duodenum proximal tubule parotid gland crypt of lieberkuhn of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GDP binding GTP binding protein binding GTPase activity Cellular component recycling endosome endosome cell projection membrane melanosome plasma membrane endocytic vesicle intracellular anatomical structure soma recycling endosome membrane dendrite basolateral plasma membrane early endosome apical plasma membrane extracellular exosome Biological process regulation of endocytosis regulation of filopodium assembly regulation of synapse assembly filopodium assembly regulation of dendrite development transcytosis establishment of melanosome localization melanosome transport endocytic recycling protein transport immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor cilium assembly transport intracellular protein transport Rab protein signal transduction small GTPase mediated signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64284 19329 Ensembl ENSG00000124839 ENSMUSG00000026304 UniProt Q9H0T7 P35292 RefSeq (mRNA) NM_022449 NM_001159725 NM_008998 RefSeq (protein) NP_071894 NP_071894.1 NP_001153197 NP_033024 Location (UCSC) Chr 2: 237.57 – 237.6 Mb Chr 1: 90.89 – 90.9 Mb PubMed search
Wikidata
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Ras-related protein Rab-17 is a protein that in humans is encoded by the RAB17 gene.

In melanocytic cells RAB17 gene expression may be regulated by MITF.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000124839 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000026304 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hunziker W, Peters PJ (Jul 1998). "Rab17 localizes to recycling endosomes and regulates receptor-mediated transcytosis in epithelial cells". J Biol Chem. 273 (25): 15734–41. doi:10.1074/jbc.273.25.15734. PMID 9624171.
6. "Entrez Gene: RAB17 RAB17, member RAS oncogene family".
7. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Lütcke A, Jansson S, Parton RG, et al. (1993). "Rab17, a novel small GTPase, is specific for epithelial cells and is induced during cell polarization". J. Cell Biol. 121 (3): 553–64. doi:10.1083/jcb.121.3.553. PMC 2119572. PMID 8486736.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Bucci C, Chiariello M, Lattero D, et al. (1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1)". Biochem. Biophys. Res. Commun. 258 (3): 657–62. doi:10.1006/bbrc.1999.0651. PMID 10329441.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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