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RAB3D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GF9
Identifiers
Aliases	RAB3D, D2-2, GOV, RAB16, RAD3D, member RAS oncogene family
External IDs	OMIM: 604350; MGI: 97844; HomoloGene: 20902; GeneCards: RAB3D; OMA:RAB3D - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.2 Start 11,322,068 bp End 11,346,270 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A3 Start 21,818,787 bp End 21,829,488 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland spinal ganglia human penis nipple skin of thigh mucosa of pharynx vulva blood cardia trigeminal ganglion Top expressed in lacrimal gland granulocyte salivary gland lumbar spinal ganglion epithelium of stomach corneal stroma submandibular gland pyloric antrum parotid gland conjunctival fornix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding myosin V binding GTP-dependent protein binding GTPase activity Cellular component zymogen granule cytoplasmic microtubule secretory vesicle extracellular exosome transport vesicle mitochondrion membrane plasma membrane azurophil granule membrane endosome synaptic vesicle vesicle Biological process regulation of exocytosis protein transport peptidyl-cysteine methylation bone resorption positive regulation of regulated secretory pathway exocytosis neutrophil degranulation transport intracellular protein transport vesicle docking involved in exocytosis protein secretion Rab protein signal transduction protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9545 19340 Ensembl ENSG00000105514 ENSMUSG00000019066 UniProt O95716 P35276 RefSeq (mRNA) NM_004283 NM_031874 NM_001324531 RefSeq (protein) NP_004274 NP_001311460 NP_114080 Location (UCSC) Chr 19: 11.32 – 11.35 Mb Chr 9: 21.82 – 21.83 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Ras-related protein Rab-3D is a protein that in humans is encoded by the RAB3D gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000105514 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000019066 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nishio H, Suda T, Sawada K, Miyamoto T, Koike T, Yamaguchi Y (Mar 1999). "Molecular cloning of cDNA encoding human Rab3D whose expression is upregulated with myeloid differentiation". Biochim Biophys Acta. 1444 (2): 283–90. doi:10.1016/s0167-4781(98)00279-6. PMID 10023084.
6. Chen XN, Shi ZY, Korenberg JR, Sehgal A (Mar 1999). "Assignment of the GOV (Glioblastoma overexpressed) gene to human chromosome band 19p13.2 by fluorescence in situ hybridization". Cytogenet Cell Genet. 83 (3–4): 230–1. doi:10.1159/000015187. PMID 10072586. S2CID 24430172.
7. "Entrez Gene: RAB3D RAB3D, member RAS oncogene family".

Further reading

• Brondyk WH, McKiernan CJ, Fortner KA, et al. (1995). "Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A". Mol. Cell. Biol. 15 (3): 1137–43. doi:10.1128/MCB.15.3.1137. PMC 230335. PMID 7532276.
• Sehgal A, Keener C, Boynton AL, et al. (1997). "Isolation and characterization of a novel gene from human glioblastoma multiforme tumor tissue". Int. J. Cancer. 71 (4): 565–72. doi:10.1002/(SICI)1097-0215(19970516)71:4<565::AID-IJC10>3.0.CO;2-B. PMID 9178809.
• Raffaniello RD, Raufman JP (1999). "Cytosolic RAB3D is associated with RAB escort protein (REP), not RAB-GDP dissociation inhibitor (GDI), in dispersed chief cells from guinea pig stomach". J. Cell. Biochem. 72 (4): 540–8. doi:10.1002/(SICI)1097-4644(19990315)72:4<540::AID-JCB9>3.0.CO;2-D. PMID 10022613. S2CID 35820873.
• Cartel NJ, Wang J, Post M (2002). "Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through Akt". Biochem. J. 363 (Pt 1): 19–28. doi:10.1042/0264-6021:3630019. PMC 1222446. PMID 11903042.
• Riedel D, Antonin W, Fernandez-Chacon R, et al. (2002). "Rab3D Is Not Required for Exocrine Exocytosis but for Maintenance of Normally Sized Secretory Granules". Mol. Cell. Biol. 22 (18): 6487–97. doi:10.1128/MCB.22.18.6487-6497.2002. PMC 135623. PMID 12192047.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Fukuda M (2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". J. Biol. Chem. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.
• Nguyen D, Jones A, Ojakian GK, et al. (2003). "Rab3D redistribution and function in rat parotid acini". J. Cell. Physiol. 197 (3): 400–8. doi:10.1002/jcp.10373. PMID 14566969. S2CID 33152672.
• Matsumoto M, Miki T, Shibasaki T, et al. (2004). "Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells". Proc. Natl. Acad. Sci. U.S.A. 101 (22): 8313–8. Bibcode:2004PNAS..101.8313M. doi:10.1073/pnas.0306709101. PMC 420391. PMID 15159548.
• Knop M, Aareskjold E, Bode G, Gerke V (2005). "Rab3D and annexin A2 play a role in regulated secretion of vWF, but not tPA, from endothelial cells". EMBO J. 23 (15): 2982–92. doi:10.1038/sj.emboj.7600319. PMC 514934. PMID 15257287.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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