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RAPGEF5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WGY
Identifiers
Aliases	RAPGEF5, GFR, MR-GEF, REPAC, Rap guanine nucleotide exchange factor 5, MRGEF
External IDs	OMIM: 609527; MGI: 2444365; HomoloGene: 56563; GeneCards: RAPGEF5; OMA:RAPGEF5 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7p15.3 Start 22,118,236 bp End 22,357,154 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 F2 Start 117,480,099 bp End 117,723,472 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior ganglion of vagus nerve Pons inferior olivary nucleus corpus callosum superior vestibular nucleus pars reticulata subthalamic nucleus postcentral gyrus external globus pallidus dorsal motor nucleus of vagus nerve Top expressed in superior cervical ganglion otolith organ utricle anterior amygdaloid area right lung lateral septal nucleus zygote left lung lobe oocyte secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTP-dependent protein binding guanyl-nucleotide exchange factor activity Cellular component nucleus nucleoplasm nuclear body Biological process small GTPase mediated signal transduction nervous system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9771 217944 Ensembl ENSG00000136237 ENSMUSG00000041992 UniProt Q92565 Q8C0Q9 RefSeq (mRNA) NM_012294 NM_001367600 NM_001367601 NM_001367602 NM_001367603 NM_175930 NM_001373989 RefSeq (protein) NP_036426 NP_001354529 NP_001354530 NP_001354531 NP_001354532 NP_787126 NP_001360918 Location (UCSC) Chr 7: 22.12 – 22.36 Mb Chr 12: 117.48 – 117.72 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Rap guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the RAPGEF5 gene.

Members of the RAS subfamily (see HRAS; MIM 190020) of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).

References

1. ^ GRCh38: Ensembl release 89: ENSG00000136237 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000041992 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
6. Ichiba T, Hoshi Y, Eto Y, Tajima N, Kuraishi Y (Oct 1999). "Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1". FEBS Lett. 457 (1): 85–9. doi:10.1016/S0014-5793(99)01012-1. PMID 10486569. S2CID 20296877.
7. ^ "Entrez Gene: RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5".

Further reading

• de Rooij J, Rehmann H, van Triest M, et al. (2000). "Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs". J. Biol. Chem. 275 (27): 20829–36. doi:10.1074/jbc.M001113200. PMID 10777494.
• Rebhun JF, Castro AF, Quilliam LA (2001). "Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction". J. Biol. Chem. 275 (45): 34901–8. doi:10.1074/jbc.M005327200. PMID 10934204.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Dupuy AG, L'Hoste S, Cherfils J, et al. (2005). "Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac". Oncogene. 24 (28): 4509–20. doi:10.1038/sj.onc.1208647. PMID 15856025.

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