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RCHY1

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Protein-coding gene in the species Homo sapiens
RCHY1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2JRJ, 2K2C, 2K2D

Identifiers
AliasesRCHY1, ARNIP, CHIMP, PIRH2, PRO1996, RNF199, ZCHY, ZNF363, ring finger and CHY zinc finger domain containing 1
External IDsOMIM: 607680; MGI: 1915348; HomoloGene: 22894; GeneCards: RCHY1; OMA:RCHY1 - orthologs
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)
Chromosome 5 (mouse)Genomic location for RCHY1Genomic location for RCHY1
Band5|5 E2Start92,096,763 bp
End92,110,927 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • secondary oocyte

  • endothelial cell

  • germinal epithelium

  • islet of Langerhans

  • right ventricle

  • biceps brachii

  • parietal pleura

  • Brodmann area 23

  • palpebral conjunctiva
Top expressed in
  • interventricular septum

  • zygote

  • granulocyte

  • secondary oocyte

  • endocardial cushion

  • seminal vesicula

  • parotid gland

  • medial ganglionic eminence

  • molar

  • temporal muscle
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

25898

68098

Ensembl

n/a

ENSMUSG00000029397

UniProt

Q96PM5

Q9CR50

RefSeq (mRNA)
NM_001008925
NM_001009922
NM_001278536
NM_001278537
NM_001278538

NM_001278539
NM_015436
NM_001387136
NM_001387137

NM_001271797
NM_026557

RefSeq (protein)
NP_001009922
NP_001265465
NP_001265466
NP_001265467
NP_001265468

NP_056251

NP_001258726
NP_080833

Location (UCSC)n/aChr 5: 92.1 – 92.11 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

RING finger and CHY zinc finger domain-containing protein 1 is a protein that in humans is encoded by the RCHY1 gene.

Function

The protein encoded by this gene has ubiquitin-protein ligase activity. This protein binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. This gene is oncogenic because loss of p53 function contributes directly to malignant tumor development. Transcription of this gene is regulated by p53. Alternative splicing results in multiple transcript variants encoding different isoforms.

Interactions

RCHY1 has been shown to interact with P53 and Androgen receptor.

References

  1. ^ GRCm38: Ensembl release 89: ENSMUSG00000029397Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Entrez Gene: RCHY1 ring finger and CHY zinc finger domain containing 1".
  5. Leng RP, Lin Y, Ma W, Wu H, Lemmers B, Chung S, Parant JM, Lozano G, Hakem R, Benchimol S (Mar 2003). "Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation". Cell. 112 (6): 779–91. doi:10.1016/S0092-8674(03)00193-4. PMID 12654245. S2CID 9316769.
  6. Sheng Y, Laister RC, Lemak A, Wu B, Tai E, Duan S, Lukin J, Sunnerhagen M, Srisailam S, Karra M, Benchimol S, Arrowsmith CH (Dec 2008). "Molecular basis of Pirh2-mediated p53 ubiquitylation". Nature Structural & Molecular Biology. 15 (12): 1334–42. doi:10.1038/nsmb.1521. PMC 4075976. PMID 19043414.
  7. Beitel LK, Elhaji YA, Lumbroso R, Wing SS, Panet-Raymond V, Gottlieb B, Pinsky L, Trifiro MA (Aug 2002). "Cloning and characterization of an androgen receptor N-terminal-interacting protein with ubiquitin-protein ligase activity". Journal of Molecular Endocrinology. 29 (1): 41–60. doi:10.1677/jme.0.0290041. PMID 12200228.

Further reading

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