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RCN2
Identifiers
Aliases	RCN2, E6BP, ERC-55, ERC55, TCBP49, reticulocalbin 2
External IDs	OMIM: 602584; MGI: 1349765; HomoloGene: 2176; GeneCards: RCN2; OMA:RCN2 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q24.3 Start 76,931,738 bp End 76,954,393 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 B Start 55,949,129 bp End 55,969,166 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis tibia caput epididymis embryo ventricular zone ganglionic eminence cartilage tissue retinal pigment epithelium endometrium tail of epididymis Top expressed in saccule otic placode dorsomedial hypothalamic nucleus spermatocyte paraventricular nucleus of hypothalamus mammillary body arcuate nucleus lateral hypothalamus median eminence otic vesicle More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 5955 26611 Ensembl ENSG00000117906 ENSMUSG00000032320 UniProt Q14257 Q8BP92 RefSeq (mRNA) NM_002902 NM_001271837 NM_001278274 NM_011992 RefSeq (protein) NP_001258766 NP_002893 NP_001265203 NP_036122 Location (UCSC) Chr 15: 76.93 – 76.95 Mb Chr 9: 55.95 – 55.97 Mb PubMed search
Wikidata
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Reticulocalbin-2 is a protein that in humans is encoded by the RCN2 gene.

Reticulocalbin 2 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. The RCN2 gene maps to the same region as type 4 Bardet-Biedl syndrome (MIM:600374), suggesting a possible causative role for reticulocalbin 2 in the disorder.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000117906 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000032320 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wang JY, Zhen DK, Bianchi DW, Androphy EJ, Chen JJ (Apr 1998). "Assignment of the gene for ERC-55 (RCN2) to human chromosome band 15q22.33→q24.1 by in situ hybridization". Cytogenet Cell Genet. 79 (1–2): 60–1. doi:10.1159/000134683. PMID 9533013.
6. Chen JJ, Reid CE, Band V, Androphy EJ (Aug 1995). "Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein". Science. 269 (5223): 529–31. Bibcode:1995Sci...269..529C. doi:10.1126/science.7624774. PMID 7624774.
7. ^ "Entrez Gene: RCN2 reticulocalbin 2, EF-hand calcium binding domain".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kirkpatrick LL, Matzuk MM, Dodds DC, Perin MS (2000). "Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2". J. Biol. Chem. 275 (23): 17786–92. doi:10.1074/jbc.M002254200. PMID 10748068.
• Dodds DC, Omeis IA, Cushman SJ, et al. (1997). "Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49". J. Biol. Chem. 272 (34): 21488–94. doi:10.1074/jbc.272.34.21488. PMID 9261167.
• Weis K, Griffiths G, Lamond AI (1994). "The endoplasmic reticulum calcium-binding protein of 55 kDa is a novel EF-hand protein retained in the endoplasmic reticulum by a carboxyl-terminal His-Asp-Glu-Leu motif". J. Biol. Chem. 269 (29): 19142–50. doi:10.1016/S0021-9258(17)32286-X. PMID 8034671.

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• Genes on human chromosome 15
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• EF-hand-containing proteins