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RG7795

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Chemical compound Pharmaceutical compound
RG7795
Clinical data
Other namesRG-7795; ANA773; ANA-773
Legal status
Legal status
  • Investigational
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
Chemical and physical data
FormulaC12H14N4O5S
Molar mass326.33 g·mol
3D model (JSmol)
SMILES
  • O=C1N(C=2C(S1)=CN=C(N)N2)3((OC(C)=O)C(CO)O3)
InChI
  • InChI=1S/C12H14N4O5S/c1-5(18)20-7-2-6(4-17)21-10(7)16-9-8(22-12(16)19)3-14-11(13)15-9/h3,6-7,10,17H,2,4H2,1H3,(H2,13,14,15)/t6-,7+,10+/m0/s1
  • Key:HOOMGTNENMZAFP-NYNCVSEMSA-N

RG7795 (previously ANA773) is an antiviral drug candidate that as of 2015 had been in Phase II trials in hepatitis B. It is an orally-available prodrug of isatoribine, that was under development by Anadys Pharmaceuticals when it was acquired by Roche in 2011. Its active metabolite is an agonist of TLR7; activation of TLR7 causes secretion of endogenous type 1 interferons, which have antiviral activity.

Chemical structure of isatoribine

As of 2021, development of RG7795 appears to be discontinued.

References

  1. "RG 7795". AdisInsight. Springer Nature Switzerland AG. Retrieved 28 August 2017.
  2. ^ Funk E, Kottilil S, Gilliam B, Talwani R (May 2014). "Tickling the TLR7 to cure viral hepatitis". Journal of Translational Medicine. 12: 129. doi:10.1186/1479-5876-12-129. PMC 4039542. PMID 24884741.
  3. "Inovio Goes It Alone on Hepatitis B Immunotherapy Vaccine as Roche Ends Collaboration". Genetic Engineering News. August 3, 2016.
  4. Sachin Bhagchandani, Jeremiah A.Johnson, and Darrell J.Irvine (2021). "Evolution of Toll-like receptor 7/8 agonist therapeutics and their delivery approaches: From antiviral formulations to vaccine adjuvants". Advanced Drug Delivery Reviews. 175: 113803. doi:10.1016/j.addr.2021.05.013. PMC 9003539. PMID 34058283.{{cite journal}}: CS1 maint: multiple names: authors list (link)
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