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RHPN2

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Protein-coding gene in the species Homo sapiens
RHPN2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2VSV

Identifiers
AliasesRHPN2, P76RBE, RHOBP, rhophilin, Rho GTPase binding protein 2, rhophilin Rho GTPase binding protein 2
External IDsOMIM: 617932; MGI: 1289234; HomoloGene: 12407; GeneCards: RHPN2; OMA:RHPN2 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)
Chromosome 19 (human)Genomic location for RHPN2Genomic location for RHPN2
Band19q13.11Start32,978,592 bp
End33,064,888 bp
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)
Chromosome 7 (mouse)Genomic location for RHPN2Genomic location for RHPN2
Band7 B2|7 21.36 cMStart35,033,595 bp
End35,091,714 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pancreatic epithelial cell

  • pancreatic ductal cell

  • mucosa of ileum

  • oocyte

  • bronchial epithelial cell

  • mucosa of sigmoid colon

  • parotid gland

  • secondary oocyte

  • jejunal mucosa

  • germinal epithelium
Top expressed in
  • secondary oocyte

  • primary oocyte

  • zygote

  • parotid gland

  • submandibular gland

  • epithelium of stomach

  • lacrimal gland

  • left colon

  • migratory enteric neural crest cell

  • vestibular membrane of cochlear duct
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

85415

52428

Ensembl

ENSG00000131941

ENSMUSG00000030494

UniProt

Q8IUC4

Q8BWR8

RefSeq (mRNA)

NM_033103

NM_027897

RefSeq (protein)

NP_149094

NP_082173

Location (UCSC)Chr 19: 32.98 – 33.06 MbChr 7: 35.03 – 35.09 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Rhophilin-2 is a protein that in humans is encoded by the RHPN2 gene.

Interactions

RHPN2 has been shown to interact with RHOB.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000131941Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000030494Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Peck JW, Oberst M, Bouker KB, Bowden E, Burbelo PD (November 2002). "The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization". J. Biol. Chem. 277 (46): 43924–32. doi:10.1074/jbc.M203569200. PMID 12221077.
  6. "Entrez Gene: RHPN2 rhophilin, Rho GTPase binding protein 2".
  7. Mircescu H, Steuve S, Savonet V, Degraef C, Mellor H, Dumont JE, Maenhaut C, Pirson I (December 2002). "Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP" (PDF). Eur. J. Biochem. 269 (24): 6241–9. doi:10.1046/j.1432-1033.2002.03343.x. PMID 12473120. S2CID 23901713.

Further reading


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