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RINT1
Identifiers
Aliases	RINT1, RINT-1, RAD50 interactor 1, ILFS3
External IDs	OMIM: 610089; MGI: 1916233; HomoloGene: 11070; GeneCards: RINT1; OMA:RINT1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q22.3 Start 105,532,169 bp End 105,567,677 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 A3 Start 23,992,709 bp End 24,025,367 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia testicle body of pancreas muscle of thigh gastrocnemius muscle right uterine tube Achilles tendon skin of abdomen skin of leg cerebellar hemisphere Top expressed in Rostral migratory stream spermatocyte tail of embryo islet of Langerhans fossa right kidney esophagus genital tubercle stomach neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm Dsl1/NZR complex endoplasmic reticulum membrane endoplasmic reticulum membrane cytosol Biological process protein transport cell cycle regulation of ER to Golgi vesicle-mediated transport Golgi vesicle transport vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Golgi organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 60561 72772 Ensembl ENSG00000135249 ENSMUSG00000028999 UniProt Q6NUQ1 Q8BZ36 RefSeq (mRNA) NM_021930 NM_001346599 NM_001346600 NM_001346601 NM_001346603 NM_177323 NM_001310467 RefSeq (protein) NP_001333528 NP_001333529 NP_001333530 NP_001333532 NP_068749 NP_001297396 NP_796297 Location (UCSC) Chr 7: 105.53 – 105.57 Mb Chr 5: 23.99 – 24.03 Mb PubMed search
Wikidata
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RAD50-interacting protein 1 is a protein that in humans is encoded by the RINT1 gene.

Interactions

RINT1 has been shown to interact with Rad50 and ZW10.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000135249 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000028999 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Xiao J, Liu CC, Chen PL, Lee WH (Mar 2001). "RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control". J Biol Chem. 276 (9): 6105–11. doi:10.1074/jbc.M008893200. PMID 11096100.
6. ^ Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, Tani K, Yamamoto A, Tohyama M, Tagaya M (Mar 2004). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". EMBO J. 23 (6): 1267–78. doi:10.1038/sj.emboj.7600135. PMC 381410. PMID 15029241.
7. "Entrez Gene: RINT1 RAD50 interactor 1".

Further reading

• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Nakajima K, Hirose H, Taniguchi M, et al. (2005). "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion". EMBO J. 23 (16): 3216–26. doi:10.1038/sj.emboj.7600333. PMC 514507. PMID 15272311.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Arasaki K, Taniguchi M, Tani K, Tagaya M (2006). "RINT-1 Regulates the Localization and Entry of ZW10 to the Syntaxin 18 Complex". Mol. Biol. Cell. 17 (6): 2780–8. doi:10.1091/mbc.E05-10-0973. PMC 1474792. PMID 16571679.
• Kong LJ, Meloni AR, Nevins JR (2006). "The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1". Mol. Cell. 22 (1): 63–71. doi:10.1016/j.molcel.2006.02.016. PMID 16600870.
• Lin X, Liu CC, Gao Q, et al. (2007). "RINT-1 Serves as a Tumor Suppressor and Maintains Golgi Dynamics and Centrosome Integrity for Cell Survival". Mol. Cell. Biol. 27 (13): 4905–16. doi:10.1128/MCB.02396-06. PMC 1951495. PMID 17470549.
• Sun Y, Shestakova A, Hunt L, et al. (2007). "Rab6 Regulates Both ZW10/RINT-1– and Conserved Oligomeric Golgi Complex-dependent Golgi Trafficking and Homeostasis". Mol. Biol. Cell. 18 (10): 4129–42. doi:10.1091/mbc.E07-01-0080. PMC 1995728. PMID 17699596.

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