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In enzymology, an RNA ligase (ATP) (EC 6.5.1.3) is an enzyme that catalyzes the chemical reaction ATP + (ribonucleotide)n + (ribonucleotide)m ${\displaystyle \rightleftharpoons }$ AMP + diphosphate + (ribonucleotide)nm. Their three substrates are ATP, (ribonucleotide)n and (ribonucleotide)m, and their three products are AMP, diphosphate and (ribonucleotide)n+m.

These enzymes belong to the family of ligases, specifically those forming phosphoric-ester bonds. The systematic name of this enzyme class is poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming). Other names in common use include polyribonucleotide synthase (ATP), RNA ligase, polyribonucleotide ligase and ribonucleic ligase.

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1VDX and 2C5U.

References

• Silber R, Malathi VG, Hurwitz J (1972). "Purification and properties of bacteriophage T4-induced RNA ligase". Proc. Natl. Acad. Sci. U.S.A. 69 (10): 3009–13. Bibcode:1972PNAS...69.3009S. doi:10.1073/pnas.69.10.3009. PMC 389696. PMID 4342972.

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