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ROSA26

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ROSA26 is a locus used for constitutive, ubiquitous gene expression in mice. It was first isolated in 1991 by the group of Philippe Soriano in a gene-trap mutagenesis screen of embryonic stem cells (ESCs). Over 800 knock-in lines have been created based on the ROSA26 locus according to the MGI database. The human homolog of the ROSA26 locus has been identified. ROSA stands for Reverse Orientation Splice Acceptor, named after the lentivirus genetrap vector.

References

  1. "rosa26". Retrieved 8 January 2013.
  2. Friedrich, G; Soriano, P (1991). "Promoter traps in embryonic stem cells: A genetic screen to identify and mutate developmental genes in mice". Genes & Development. 5 (9): 1513–23. doi:10.1101/gad.5.9.1513. PMID 1653172.
  3. "Gt(ROSA)26Sor MGI Mouse Gene Detail - MGI:104735 - gene trap ROSA 26, Philippe Soriano". www.informatics.jax.org. Retrieved 2023-09-30.
  4. Irion, Stefan; Luche, Hervé; Gadue, Paul; Fehling, Hans Joerg; Kennedy, Marion; Keller, Gordon (2007). "Identification and targeting of the ROSA26 locus in human embryonic stem cells". Nature Biotechnology. 25 (12): 1477–82. doi:10.1038/nbt1362. PMID 18037879. S2CID 10292785.
  5. Friedrich, G.; Soriano, P. (September 1991). "Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice". Genes & Development. 5 (9): 1513–1523. doi:10.1101/gad.5.9.1513. ISSN 0890-9369. PMID 1653172.
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