Rabbit vesivirus (RaV) is a Caliciviridae virus that was first isolated in the Veterinary Diagnostic Laboratory at Oregon State University, from the feces of rabbits suffering from gastrointestinal disease. The virus is a non-enveloped, isometric virus with diameter of around 30 nanometer.
Its viral genome is 8,295 nucleotides in size, consisting of positive single-stranded RNA with a small protein (VPg) covalently linked to its 5′ terminus and a 3′ poly-A tail with an average length of 85 nucleotides. The genome comprises three open reading frames, the most 5′ of which encodes a 1,880 amino acid proteolysis that yields the non-structural polypeptides upon self-cleavage. The vesivirus is the only genus of which all members are cultivable.
Reference
- Álvarez, Ángel L.; García-Manso, Alberto; Dalton, Kevin P.; Martín-Alonso, José M.; Nicieza, Inés; Podadera, Ana; Acosta-Zaldívar, Maikel; de Llano, Daniel; Parra, Francisco (2020). "Reverse Genetics System for Rabbit vesivirus". Frontiers in Microbiology. 11. doi:10.3389/fmicb.2020.596245. ISSN 1664-302X. PMC 7693663. PMID 33304341.
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