Misplaced Pages

Ram I. Mahato

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Nepalese-American scientist (born 1963)
This article has multiple issues. Please help improve it or discuss these issues on the talk page. (Learn how and when to remove these messages)
This biography of a living person needs additional citations for verification. Please help by adding reliable sources. Contentious material about living persons that is unsourced or poorly sourced must be removed immediately from the article and its talk page, especially if potentially libelous.
Find sources: "Ram I. Mahato" – news · newspapers · books · scholar · JSTOR (January 2019) (Learn how and when to remove this message)
This biography of a living person relies on a single source. You can help by adding reliable sources to this article. Contentious material about living people that is unsourced or poorly sourced must be removed immediately. (January 2019) (Learn how and when to remove this message)
This article may rely excessively on sources too closely associated with the subject, potentially preventing the article from being verifiable and neutral. Please help improve it by replacing them with more appropriate citations to reliable, independent, third-party sources. (January 2019) (Learn how and when to remove this message)
(Learn how and when to remove this message)
Dr. Ram I. Mahato
Born(1963-01-11)January 11, 1963
Janakpurdham, Nepal
Alma materUniversity of Nebraska Medical Center, Omaha
Scientific career
FieldsPolymeric Nanomedicine

Ram I. Mahato is a professor and chairman of the Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, United States. He was Professor of Pharmaceutical Sciences and Biomedical Engineering at the University of Tennessee Health Science Center, Memphis. He was Research Assistant Professor at the University of Utah, Senior Scientist at GeneMedicine Inc and a postdoctoral fellow at the University of Southern California, Washington University in St. Louis, and Kyoto University. He received a PhD in drug delivery from the University of Strathclyde and BS from China Pharmaceutical University. He is a CRS Fellow, AAPS Fellow, Permanent Member of BTSS/NIH Study section (2009–2013), and ASGCT Scientific Advisor (nonviral vectors, 2006–2009).

Research activities

He has expertise in molecular and cell biology, biochemistry, biophysics, polymer chemistry, colloid science, pharmaceutics, and medicine. It allowed him to take a multidisciplinary approach for successful research and training students and post-doctoral fellows. His research is focused on the following areas: (i) micelle and nanoparticulate drug delivery, (ii) oligonucleotides, siRNA, miRNA, shRNA and gene delivery (iii) synthesis of novel polymers, lipopeptides, lipopolymers and cationic lipids (iv) construction of plasmid and adenovirus-based gene and shRNA expression systems. These systems are being tested in various disease areas such as improving islet transplantation to treat type 1 diabetes, cancer (pancreatic, prostate and breast) and liver fibrosis.

Research accomplishments

  • Delivery and targeting of oligonucleotide and siRNA-based therapies: contributed extensively on the use of antisense and antigene oligonucleotides as well as siRNA for treating liver fibrosis, diabetes and cancer.
  • Cell-based therapeutics: contributed extensively on genetic modification of human islets for improved islet transplantation.
  • Polymeric nanomedicines and combination therapy. Contributed extensively on polymeric micellar delivery using novel polymers and combination therapy for treating advanced prostate cancer.
  • Cytokine gene therapy: Contributed extensively on the use of interleukin-12 (IL-12), interferon-gamma (IFN-γ), vascular endothelial growth factor (VEGF) and growth hormone gene delivery to tumor and diabetes animal models.
  • Design of gene delivery systems: Developed polymer, lipid, lipopolymer and peptide-based systems to deliver and transfect oligonucleotides and genes to specific organs in vivo and different cell lines in vitro.
  • Formulation sciences: formulated various small drugs, proteins, oligonucleotides and plasmids for in vitro and in vivo studies.
  • Drug delivery and pharmacokinetics: determined the pharmacokinetic profiles of small molecules, proteins, oligonucleotides and genes using mice, rats and rabbits.
  • Synthesis: synthesized water-soluble and insoluble lipopolymers, soluble steroidal peptides, cationic lipids, and conjugated galactose, mannose and FITC to polylysine for gene delivery.
  • Particulate carrier systems: developed various polymeric nanoparticulate carrier systems.
  • Lyophilization: lyophilized anticancer drugs and lipid/plasmid complexes.
  • Intracellular trafficking: Investigated the mechanism of cellular uptake and intracellular trafficking of plasmids and oligonucleotides.

References

  1. "Ram I. Mahato". unmc.edu. Retrieved 2015-01-04.
Categories: