Reactive gastropathy - Misplaced Pages

Medical condition

Reactive gastropathy

Micrograph of a reactive gastropathy. H&E stain.
Specialty	Pathology, gastroenterology

Reactive gastropathy, chemical gastropathy also called gastritis of « C type » or "chemical gastritis" is an abnormality in the stomach caused by chemicals, e.g. bile, alcohol, and characteristically has minimal inflammation.

Cause

Reactive gastropathy has a large number of causes, including:

Alcohol use disorder.
Bile reflux, such as may be seen post-Billroth II.
NSAIDs.

Diagnosis

The diagnosis is by examination of tissue, e.g. a stomach biopsy.

Low mag.
High mag.

Relation to gastritis

Reactive gastropathy is morphologically distinct entity that can be separated from gastritis, which by definition has a significant inflammatory component.

As a reactive gastropathy may mimic a (true) gastritis symptomatically and visually in an endoscopic examination, it may incorrectly be referred to as a gastritis. Even aware of the underlying etiology of the pathologic process, e.g. NSAID use, the label "chemical gastritis" is applied to a chemical gastropathy.

References

Wyatt JI, Dixon MF (1988). "Chronic gastritis—a pathogenesis approach". The Journal of Pathology. 40 (154): 113–24. doi:10.1002/path.1711540203. PMID 3280764. S2CID 28410354.
Genta, RM (Nov 2005). "Differential diagnosis of reactive gastropathy". Seminars in Diagnostic Pathology. 22 (4): 273–83. doi:10.1053/j.semdp.2006.04.001. PMID 16939055.
Pashankar, DS; Bishop, WP; Mitros, FA (Nov 2002). "Chemical gastropathy: a distinct histopathologic entity in children". Journal of Pediatric Gastroenterology and Nutrition. 35 (5): 653–7. doi:10.1097/00005176-200211000-00012. PMID 12454581. S2CID 40029728.
Dixon, MF; O'Connor, HJ; Axon, AT; King, RF; Johnston, D (May 1986). "Reflux gastritis: distinct histopathological entity?". Journal of Clinical Pathology. 39 (5): 524–30. doi:10.1136/jcp.39.5.524. PMC 499914. PMID 3722405.

External links

Classification	D
External resources	eMedicine: article/1962893

Reactive gastropathy - surgical pathology criteria (stanford.edu).

Diseases of the human digestive system

Upper GI tract

Esophagus

Stomach

Lower GI tract
Enteropathy

Small intestine (Duodenum/Jejunum/Ileum)	Enteritis Duodenitis Jejunitis Ileitis Peptic (duodenal) ulcer Curling's ulcer Malabsorption: Coeliac Tropical sprue Blind loop syndrome Small intestinal bacterial overgrowth Whipple's Short bowel syndrome Steatorrhea Milroy disease Bile acid malabsorption
Large intestine (Appendix/Colon)	Appendicitis Colitis Pseudomembranous Ulcerative Ischemic Microscopic Collagenous Lymphocytic Dysentery Functional colonic disease IBS Intestinal pseudoobstruction / Ogilvie syndrome Megacolon / Toxic megacolon Diverticulitis/Diverticulosis/SCAD
Large and/or small	Enterocolitis Necrotizing Gastroenterocolitis IBD Crohn's disease Vascular: Abdominal angina Mesenteric ischemia Angiodysplasia Bowel obstruction: Ileus Intussusception Volvulus Fecal impaction Constipation Functional Diarrhea Infectious Intestinal adhesions
Rectum	Proctitis Radiation proctitis Proctalgia fugax Rectal prolapse Anismus Solitary rectal ulcer syndrome Rectal stricture
Anal canal	Anal fissure/Anal fistula Anal abscess Hemorrhoid Anal dysplasia Pruritus ani Anal stricture

GI bleeding

Accessory

Liver	Hepatitis Viral hepatitis Autoimmune hepatitis Alcoholic hepatitis Cirrhosis PBC Fatty liver MASLD Vascular Budd–Chiari syndrome Hepatic veno-occlusive disease Portal hypertension Nutmeg liver Alcoholic liver disease Liver failure Hepatic encephalopathy Acute liver failure Liver abscess Pyogenic Amoebic Hepatorenal syndrome Peliosis hepatis Metabolic disorders Wilson's disease Hemochromatosis
Gallbladder	Cholecystitis Gallstone / Cholelithiasis Cholesterolosis Adenomyomatosis Postcholecystectomy syndrome Porcelain gallbladder
Bile duct/ Other biliary tree	Cholangitis Primary sclerosing cholangitis Secondary sclerosing cholangitis Ascending Cholestasis/Mirizzi's syndrome Biliary fistula Haemobilia Common bile duct Choledocholithiasis Biliary dyskinesia Sphincter of Oddi dysfunction
Pancreatic	Pancreatitis Acute Chronic Hereditary Pancreatic abscess Pancreatic pseudocyst Exocrine pancreatic insufficiency Pancreatic fistula

Other

Hernia

Lumbar
- Petit's
- Grynfeltt–Lesshaft

Undefined location

Peritoneal

Inflammation

Symptoms

Mechanism

Acute

Plasma-derived mediators

Cell-derived mediators

preformed	Lysosome granules biogenic amines Histamine Serotonin
synthesized on demand	cytokines IFN-γ IL-8 TNF-α IL-1 eicosanoids Leukotriene B4 Prostaglandins Nitric oxide Kinins

Chronic

Other

Tests

General

Categories:

Cause

Diagnosis

Relation to gastritis

See also

References

External links