Region 8 or Region VIII can refer to:
- One of DVD region
- Former Region 8 (Johannesburg), an administrative district in the city of Johannesburg, South Africa, from 2000 to 2006
- Biobío Region, Chile
- Eastern Visayas Region, Philippines
- KAIT, a television station located in Jonesboro, Arkansas branded as Region 8
- NJCAA Region 8, an intercollegiate athletics region
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