Names | |
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IUPAC name (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-yl acetate | |
Other names Retinol acetate; Vitamin A acetate; Vitamin A1 acetate; Acetylretinol; all-trans-Retinol acetate; all-trans-Retinyl acetate; all-trans-Vitamin A acetate; | |
Identifiers | |
CAS Number | |
3D model (JSmol) | |
Beilstein Reference | 1915439 |
ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.004.405 |
EC Number |
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KEGG | |
PubChem CID | |
UNII | |
CompTox Dashboard (EPA) | |
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Properties | |
Chemical formula | C22H32O2 |
Molar mass | 328.496 g·mol |
Melting point | 57 to 58 °C (135 to 136 °F; 330 to 331 K) |
Hazards | |
GHS labelling: | |
Pictograms | |
Signal word | Warning |
Hazard statements | H315, H361, H413 |
Precautionary statements | P201, P202, P264, P273, P280, P281, P302+P352, P308+P313, P321, P332+P313, P362, P405, P501 |
NFPA 704 (fire diamond) | 1 1 0 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references |
Retinyl acetate (retinol acetate, vitamin A acetate) is a natural form of vitamin A which is the acetate ester of retinol. It has potential antineoplastic and chemopreventive activities.
In the United States, retinyl acetate is classified generally recognized as safe (GRAS) in the amounts used to fortify foods with vitamin A.
Toxicology
See also: Hypervitaminosis AWorld Health Organization "Recommendations for preformed vitamin A supplements for mothers during pregnancy" states that "health benefits are expected for the mother and her developing fetus with little risk of detriment to either, from a daily supplement not exceeding 10,000 IU vitamin A (3000mcg RE) at any time during pregnancy." Preformed Vitamin A refers to retinol and retinyl esters, such as retinyl palmitate and retinyl acetate.
References
- Retinyl acetate from Sigma-Aldrich
- Moon, Richard C.; Grubbs, Clinton J.; Sporn, Michael B.; Goodman, Dawn G. (1977). "Retinyl acetate inhibits mammary carcinogenesis induced by N-methyl-N-nitrosourea". Nature. 267 (5612): 620–1. Bibcode:1977Natur.267..620M. doi:10.1038/267620a0. PMID 876383. S2CID 4211886.
- Retinyl acetate, National Cancer Institute Drug Dictionary
- Select Committee on GRAS Substances (SCOGS) Opinion: Vitamin A, United States Food and Drug Administration
- 21 CFR 184.1930
- World Health Organization Nutrition Unit (1998). Safe vitamin A dosage during pregnancy and lactation. World Health Organization. hdl:10665/63838.