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Nucleus reuniens
Details
Identifiers
Latin	nucleus reuniens
NeuroNames	309
NeuroLex ID	birnlex_770
TA98	A14.1.08.632
FMA	62153
Anatomical terms of neuroanatomy[edit on Wikidata]

The nucleus reuniens is a region of the thalamic midline nuclear group. In the human brain, it is located in the interthalamic adhesion (massa intermedia). It is also known as the medioventral nucleus.

The nucleus reuniens receives afferent input from a large number of structures, mainly from limbic and limbic-associated structures. It sends projections to the medial prefrontal cortex, the hippocampus, perirhinal cortex, and entorhinal cortex, although there exist sparse connections to many other afferent structures as well.

The unique medial prefrontal cortex and hippocampal connectivity allows reuniens to regulate neural traffic in this cortical network related to changes in an organism's attentiveness, making reuniens critical to associative learning, memory retrieval, memory generalization, spatial route planning, and resilience to stress.

References

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2. Griffin, Amy L. (2015-01-01). "Role of the thalamic nucleus reuniens in mediating interactions between the hippocampus and medial prefrontal cortex during spatial working memory". Frontiers in Systems Neuroscience. 9: 29. doi:10.3389/fnsys.2015.00029. ISSN 1662-5137. PMC 4354269. PMID 25805977.
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8. Vertes, R. P. (2006). "Interactions among the medial prefrontal cortex, hippocampus and midline thalamus in emotional and cognitive processing in the rat". Neuroscience. 142 (1): 1–20. doi:10.1016/j.neuroscience.2006.06.027. PMID 16887277. S2CID 5591335.
9. Viena, Tatiana D.; Rasch, Gabriela E.; Silva, Daniela; Allen, Timothy A. (2021). "Calretinin and calbindin architecture of the midline thalamus associated with prefrontal–hippocampal circuitry". Hippocampus. 31 (7): 770–789. doi:10.1002/hipo.23271. ISSN 1050-9631. PMC 8805340. PMID 33085824.
10. Herkenham, M. (1978). "The connections of the nucleus reuniens thalami: Evidence for a direct thalamo-hippocampal pathway in the rat". The Journal of Comparative Neurology. 177 (4): 589–610. doi:10.1002/cne.901770405. PMID 624792. S2CID 7535058.
11. Vertes, R. P.; Hoover, W. B.; Szigeti-Buck, K.; Leranth, C. (2007). "Nucleus reuniens of the midline thalamus: Link between the medial prefrontal cortex and the hippocampus". Brain Research Bulletin. 71 (6): 601–609. doi:10.1016/j.brainresbull.2006.12.002. PMC 4997812. PMID 17292803.
12. Eleore, L.; López-Ramos, J. C.; Guerra-Narbona, R.; Delgado-García, J. M. (2011). Izquierdo, Ivan (ed.). "Role of Reuniens Nucleus Projections to the Medial Prefrontal Cortex and to the Hippocampal Pyramidal CA1 Area in Associative Learning". PLOS ONE. 6 (8): e23538. Bibcode:2011PLoSO...623538E. doi:10.1371/journal.pone.0023538. PMC 3156136. PMID 21858159.
13. Jayachandran, Maanasa; Linley, Stephanie B.; Schlecht, Maximilian; Mahler, Stephen V.; Vertes, Robert P.; Allen, Timothy A. (2019). "Prefrontal Pathways Provide Top-Down Control of Memory for Sequences of Events". Cell Reports. 28 (3): 640–654.e6. doi:10.1016/j.celrep.2019.06.053. PMC 6662648. PMID 31315044.
14. Xu, W.; Sudhof, T. C. (14 March 2013). "A Neural Circuit for Memory Specificity and Generalization". Science. 339 (6125): 1290–1295. Bibcode:2013Sci...339.1290X. doi:10.1126/science.1229534. PMC 3651700. PMID 23493706.
15. Ito, H. T.; Zhang, S. J.; Witter, M. P.; Moser, E. I.; Moser, M. B. (2015). "A prefrontal-thalamo-hippocampal circuit for goal-directed spatial navigation". Nature. 522 (7554): 50–5. Bibcode:2015Natur.522...50I. doi:10.1038/nature14396. hdl:11250/2493579. PMID 26017312. S2CID 205243449.
16. Kafetzopoulos, V.; Kokras, N.; Sotiropoulos, I.; Oliveira, J. F.; Leite-Almeida, H.; Vasalou, A.; Sardinha, V. M.; Papadopoulou-Daifoti, Z.; Almeida, O. F. X. (2017-04-11). "The nucleus reuniens: a key node in the neurocircuitry of stress and depression". Molecular Psychiatry. 23 (3): 579–586. doi:10.1038/mp.2017.55. ISSN 1476-5578. PMC 5822458. PMID 28397837.

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