Protein domain
RhoGEF domain describes two distinct structural domains with guanine nucleotide exchange factor (GEF) activity to regulate small GTPases in the Rho family . Rho small GTPases are inactive when bound to GDP but active when bound to GTP ; RhoGEF domains in proteins are able to promote GDP release and GTP binding to activate specific Rho family members, including RhoA , Rac1 and Cdc42 .
The largest class of RhoGEFs is composed of proteins containing the "Dbl -homology" (DH ) domain, which almost always is found together with a pleckstrin-homology (PH) domain to form a combined DH/PH domain structure.
A distinct class of RhoGEFs is those proteins containing the DOCK/CZH/DHR-2 domain. This structure has no sequence similarity with DBL-homology domains.
Human proteins containing DH/PH RhoGEF domain
ABR ; AKAP13/ARHGEF13/Lbc ; ALS2 ; ALS2CL ; ARHGEF1/p115-RhoGEF ; ARHGEF10 ; ARHGEF10L ; ARHGEF11/PDZ-RhoGEF. ; ARHGEF12/LARG ; ARHGEF15 ; ARHGEF16 ; ARHGEF17 ; ARHGEF18 ; ARHGEF19 ; ARHGEF2 ; ARHGEF25 ; ARHGEF26 ; ARHGEF28 ; ARHGEF3 ; ARHGEF33 ; ARHGEF35 ; ARHGEF37 ; ARHGEF38 ; ARHGEF39 ; ARHGEF4 ; ARHGEF40 ; ARHGEF5 ; ARHGEF6/alpha-PIX ; ARHGEF7/beta-PIX ; ARHGEF9 ; BCR ; DNMBP ; ECT2 ; ECT2L ; FARP1 ; FARP2 ; FGD1 ; FGD2 ; FGD3 ; FGD4 ; FGD5 ; FGD6 ; ITSN1/Intersectin 1 ; ITSN2/Intersectin 2 ; KALRN/Kalirin ; MCF2 ; MCF2L ; MCF2L2 ; NET1 ; NGEF ; OBSCN ; PLEKHG1 ; PLEKHG2 ; PLEKHG3 ; PLEKHG4 ; PLEKHG4B ; PLEKHG5 ; PLEKHG6 ; PREX1 ; PREX2 ; RASGRF1 ; RASGRF2 ; SPATA13 ; TIAM1 ; TIAM2 ; TRIO ; VAV1 ; VAV2 ; VAV3 .
Human proteins containing DOCK/CZH RhoGEF domain
DOCK1/DOCK180 ; DOCK2 ; DOCK3/MOCA ; DOCK4 ; DOCK5 ; DOCK6/ZIR1 ; DOCK7/ZIR2 ; DOCK8/ZIR3 ; DOCK9/Zizimin1 ; DOCK10/Zizimin2 ; DOCK11/Zizimin3
See also
References
Soisson SM, Nimnual AS, Uy M, Bar-Sagi D, Kuriyan J (October 1998). "Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein" . Cell . 95 (2): 259–68. doi :10.1016/S0092-8674(00)81756-0 . PMID 9790532 . S2CID 11868669 .
Fort P, Blangy A (June 2017). "The Evolutionary Landscape of Dbl-Like RhoGEF Families: Adapting Eukaryotic Cells to Environmental Signals" . Genome Biology and Evolution . 9 (6): 1471–1486. doi :10.1093/gbe/evx100 . PMC 5499878 . PMID 28541439 .
Cerione RA, Zheng Y (April 1996). "The Dbl family of oncogenes" . Current Opinion in Cell Biology . 8 (2): 216–22. doi :10.1016/s0955-0674(96)80068-8 . PMID 8791419 .
Côté JF, Vuori K (December 2002). "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity" . Journal of Cell Science . 115 (Pt 24): 4901–13. doi :10.1242/jcs.00219 . PMID 12432077 .
Further reading
Hart MJ, Eva A, Evans T, Aaronson SA, Cerione RA (November 1991). "Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product". Nature . 354 (6351): 311–4. doi :10.1038/354311a0 . PMID 1956381 . S2CID 4240053 . Tan EC, Leung T, Manser E, Lim L (December 1993). "The human active breakpoint cluster region-related gene encodes a brain protein with homology to guanine nucleotide exchange proteins and GTPase-activating proteins" . The Journal of Biological Chemistry . 268 (36): 27291–8. doi :10.1016/S0021-9258(19)74248-3 . PMID 8262969 . Soisson SM, Nimnual AS, Uy M, Bar-Sagi D, Kuriyan J (October 1998). "Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein" . Cell . 95 (2): 259–68. doi :10.1016/S0092-8674(00)81756-0 . PMID 9790532 . S2CID 11868669 . Categories :
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Structure of the RhoGEF domain from the human Son of sevenless protein, an example of a DH/PH domain RhoGEF.