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RNF103
Identifiers
Aliases	RNF103, HKF-1, KF-1, KF1, ZFP-103, ZFP103, ring finger protein 103
External IDs	OMIM: 602507; MGI: 109483; HomoloGene: 4146; GeneCards: RNF103; OMA:RNF103 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p11.2 Start 86,603,398 bp End 86,623,866 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6 C1|6 32.16 cM Start 71,470,878 bp End 71,487,865 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus amniotic fluid corpus epididymis jejunal mucosa Brodmann area 23 mucosa of ileum germinal epithelium trigeminal ganglion corpus callosum paraflocculus of cerebellum Top expressed in left colon ciliary body conjunctival fornix seminal vesicula substantia nigra lacrimal gland parotid gland lobe of prostate stroma of bone marrow Paneth cell More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding metal ion binding ubiquitin-protein transferase activity transferase activity ubiquitin protein ligase activity Cellular component integral component of membrane endoplasmic reticulum membrane endoplasmic reticulum membrane endoplasmic reticulum quality control compartment Biological process central nervous system development protein ubiquitination ubiquitin-dependent ERAD pathway endoplasmic reticulum mannose trimming Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7844 22644 Ensembl ENSG00000239305 ENSMUSG00000052656 UniProt O00237 Q9R1W3 RefSeq (mRNA) NM_005667 NM_001198951 NM_001198952 NM_009543 NM_001308303 RefSeq (protein) NP_001185880 NP_001185881 NP_005658 NP_001295232 NP_033569 Location (UCSC) Chr 2: 86.6 – 86.62 Mb Chr 6: 71.47 – 71.49 Mb PubMed search
Wikidata
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Ring finger protein 103 is a protein that in humans is encoded by the RNF103 gene.

Function

The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by electroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000239305 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000052656 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Ring finger protein 103". Retrieved 2017-07-04.

Further reading

• Scheper J, Oliva B, Villà-Freixa J, Thomson TM (2009). "Analysis of electrostatic contributions to the selectivity of interactions between RING-finger domains and ubiquitin-conjugating enzymes". Proteins. 74 (1): 92–103. doi:10.1002/prot.22120. PMID 18615712. S2CID 37900633.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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