Robert Lefkowitz - Misplaced Pages

(Redirected from Robert Joseph Lefkowitz) American physician and biochemist

Robert Lefkowitz
Lefkowitz in Stockholm 2012
Born	Robert Joseph Lefkowitz (1943-04-15) April 15, 1943 (age 81) The Bronx, New York City, US
Nationality	American
Alma mater	Columbia University
Known for	G protein coupled receptors beta-arrestins
Spouse(s)	Arna Brandel (divorced) Lynn Tilley (m. 1991)
Awards	National Medal of Science (2007) BBVA Foundation Frontiers of Knowledge Award (2009) Nobel Prize in Chemistry (2012)
Scientific career
Fields	Receptor Biology Biochemistry
Institutions	Duke University Howard Hughes Medical Institute
Notable students	Brian Kobilka, Jeffrey Benovic, Michel Bouvier, Marc G. Caron, Richard A. Cerione, Henrik Dohlman, Walter J. Koch, Lee Limbird, Martin J. Lohse, Gang Pei, Lewis "Rusty" Williams, R. Sanders Williams

Robert Joseph Lefkowitz (born April 15, 1943) is an American physician (internist and cardiologist) and biochemist. He is best known for his discoveries that reveal the inner workings of an important family of G protein-coupled receptors, for which he was awarded the 2012 Nobel Prize for Chemistry with Brian Kobilka. He is currently an Investigator with the Howard Hughes Medical Institute as well as a James B. Duke Professor of Medicine and Professor of Biochemistry and Chemistry at Duke University.

Early life

Lefkowitz was born on April 15, 1943, in The Bronx, New York to Jewish parents Max and Rose Lefkowitz. Their families had emigrated to the United States from Poland in the late 19th century.

After graduating from the Bronx High School of Science in 1959, he attended Columbia College from which he received a Bachelor of Arts in chemistry in 1962. At Columbia, Lefkowitz studied under Ronald Breslow.

He graduated from Columbia University College of Physicians and Surgeons in 1966 with an M.D. degree. After serving an internship and one year of general medical residency at the College of Physicians and Surgeons, he served as clinical and research associate at the National Institutes of Health from 1968 to 1970.

Career

Upon completing his medical residency and research and clinical training in 1973, he was appointed associate professor of medicine and assistant professor of biochemistry at the Duke University Medical Center. In 1977, he was promoted to professor of medicine and in 1982 to James B. Duke Professor of Medicine at Duke University. He is also a professor of biochemistry and a professor of chemistry. He has been an investigator of the Howard Hughes Medical Institute since 1976 and was an established investigator of the American Heart Association from 1973–1976.

Lefkowitz studies receptor biology and signal transduction and is most well known for his detailed characterizations of the sequence, structure and function of the β-adrenergic and related receptors and for the discovery and characterization of the two families of proteins which regulate them, the G protein-coupled receptor (GPCR) kinases and β-arrestins.

Lefkowitz made a remarkable contribution in the mid-1980s when he and his colleagues cloned the gene first for the β-adrenergic receptor, and then rapidly thereafter, for a total of 8 adrenergic receptors (receptors for adrenaline and noradrenaline). This led to the seminal discovery that all GPCRs (which include the β-adrenergic receptor) have a very similar molecular structure. The structure is defined by an amino acid sequence which weaves its way back and forth across the plasma membrane seven times. Today we know that about 1,000 receptors in the human body belong to this same family. The importance of this is that all of these receptors use the same basic mechanisms so that pharmaceutical researchers now understand how to effectively target the largest receptor family in the human body. Today, as many as 30 to 50 percent of all prescription drugs are designed to "fit" like keys into the similarly structured locks of Lefkowitz' receptors—everything from anti-histamines to ulcer drugs to beta blockers that help relieve hypertension, angina and coronary disease. Lefkowitz is among the most highly cited researchers in the fields of biology, biochemistry, pharmacology, toxicology, and clinical medicine according to Thomson-ISI.

Personal life

Lefkowitz is married to Lynn (née Tilley). He has five children and six grandchildren. He was previously married to Arna Brandel.

In 2021, Lefkowitz published a memoir entitled A Funny Thing Happened on the Way to Stockholm: The Adrenaline-Fueled Adventures of an Accidental Scientist. This book was co-authored by Randy Hall, who was a post-doctoral fellow in the Lefkowitz lab in the 1990's. The book describes Lefkowitz's early life, training as a physician, and tenure in the United States Public Health Service (the "Yellow Berets" of the NIH), which began as a means of fulfilling his draft obligation during the Vietnam War but ultimately ignited a lifelong passion for research. The second half of the book describes Lefkowitz's research career and various adventures both before and after his Nobel Prize win. Upon publication in February 2021, the book was named as "New & Noteworthy" by The New York Times and "one of the week's best science picks" by Nature.

Awards

Lefkowitz has received numerous awards including:

2014 Golden Plate Award of the American Academy of Achievement
2012 Nobel Prize in Chemistry (shared with Brian Kobilka)
2009 BBVA Foundation Frontiers of Knowledge Award, in the Biomedicine Category.
2009 Research Achievement Award, American Heart Association
2007 National Medal of Science
2007 The Shaw Prize in Life Science and Medicine
2007 Albany Medical Center Prize in Medicine and Biomedical Research
2003 Fondation Lefoulon – Delalande Grand Prix for Science – Institut de France
2001 Jessie Stevenson Kovalenko Medal of the USA – The National Academy of Sciences
1992 Bristol-Myers Squibb Award for Distinguished Achievement In Cardiovascular Research
1988 Gairdner Foundation International Award
1978 John Jacob Abel Award in Pharmacology

References

"The Nobel Prize in Chemistry 2012". NobelPrize.org.
Snyder, Bill. "Nobel in Chemistry reveals VU ties that bind". Vanderbilt University.
Ralph Snyderman (October 3, 2011). "Introduction of Robert J. Lefkowitz". The Journal of Clinical Investigation. 121 (10). Jci.org: 4192–4300. doi:10.1172/JCI60816. PMC 3195491. PMID 21965339. Retrieved October 12, 2012.
Jay Price (December 30, 2012). "Dr. Robert Lefkowitz, Nobel in hand, still shapes young researchers". News & Observer. Archived from the original on January 20, 2013. Retrieved January 17, 2013.
Newman, Andy (October 10, 2012). "Another Nobel for Bronx Science, This One in Chemistry". New York Times.
^ "Dr. Robert Lefkowitz, Nobel in hand, still shapes young researchers - Local/State - NewsObserver.com". Archived from the original on January 20, 2013. Retrieved January 17, 2013.
"Columbia College mourns the loss of University Professor Ronald Breslow". Columbia College. Retrieved June 15, 2024.
^ "HHMI Investigators – Robert J. Lefkowitz, M.D". Howard Hughes Medical Institute. Retrieved January 14, 2013.
"Robert J. Lefkowitz, M.D. Biography and Interview". www.achievement.org. American Academy of Achievement.
"Pioneers of cell receptor research share America's top prize in medicine". Albany Medical Center Website.
"Highly Cited Research – Research Analytics – Thomson Reuters". Hcr3.webofknowledge.com. December 31, 2011. Retrieved October 12, 2012.
"A Funny Thing Happened on the Way to Stockholm". pegasusbooks.com. Retrieved March 31, 2021.
"New & Noteworthy, From Food Policy to Communicating With the Dead". The New York Times. February 2, 2021. ISSN 0362-4331. Retrieved March 31, 2021.
Robinson, Andrew (March 17, 2021). "The accidental Nobel laureate, what we owe to our voices and the philosophy of touch: Books in Brief". Nature. 591 (7850): 364. Bibcode:2021Natur.591..364R. doi:10.1038/d41586-021-00661-4.
"Golden Plate Awardees of the American Academy of Achievement". www.achievement.org. American Academy of Achievement.
"Biomedicine 2009 Robert J. Lefkowitz". BBVA Foundation Frontiers of Knowledge Awards. Archived from the original on March 17, 2016. Retrieved January 14, 2013.
"North Carolina scientist wins American Heart Association award for discovering receptors' role as specific targets for drug therapy". American Heart Association. November 15, 2009. Retrieved January 14, 2013.
"Robert Lefkowitz receiving the National Medal of Science". Duke University. September 28, 2008. Archived from the original on December 21, 2021. Retrieved January 14, 2013. – YouTube video of the ceremony
Duke Medicine News and Communications (September 28, 2008). "Duke Medicine Physician-Scientist Receives National Medal of Science". Duke Health.org. Retrieved January 14, 2013.
"Announcement and Citation". The Shaw Prize. June 12, 2007. Archived from the original on April 7, 2016. Retrieved January 14, 2013.
"Albany Medical Center Prize". Albany Medical College. Archived from the original on July 17, 2012. Retrieved January 14, 2013.
"Fondation Lefoulon Delalande – Historique des prix". Fondation Lefoulon – Delalande. Retrieved January 14, 2013.
"Jessie Stevenson Kovalenko Medal". National Academy of Sciences. Retrieved January 14, 2013.
"Bristol Myers Squib Achievements". Bristol-Myers Squibb. Retrieved January 14, 2013.
"Robert J. Lefkowitz". Gairdner. Retrieved January 14, 2013.
"Previous Winners of Society Awards" (PDF). American Society for Pharmacology and Experimental Therapeutics. Retrieved January 14, 2013.

External links

"Lefkowitz Lab". Retrieved January 14, 2013. – Web site of his lab.
"Robert J. Lefkowitz, MD". HHMI. Retrieved February 23, 2024.
Robert Lefkowitz – National Medal of Science on YouTube
Robert Lefkowitz on Nobelprize.org
Lefkowitz, Robert J. (February 2, 2021). A Funny Thing Happened on the Way to Stockholm. Pegasus Books. ISBN 978-1-64313-638-7.

Awards
Preceded byDan Shechtman	Nobel Prize in Chemistry laureate 2012 With: Brian Kobilka	Succeeded byMichael Levitt Martin Karplus Arieh Warshel

v t e Shaw Prize laureates
Astronomy	Jim Peebles (2004) Geoffrey Marcy and Michel Mayor (2005) Saul Perlmutter, Adam Riess and Brian Schmidt (2006) Peter Goldreich (2007) Reinhard Genzel (2008) Frank Shu (2009) Charles Bennett, Lyman Page and David Spergel (2010) Enrico Costa and Gerald Fishman (2011) David C. Jewitt and Jane Luu (2012) Steven Balbus and John F. Hawley (2013) Daniel Eisenstein, Shaun Cole and John A. Peacock (2014) William J. Borucki (2015) Ronald Drever, Kip Thorne and Rainer Weiss (2016) Simon White (2017) Jean-Loup Puget (2018) Edward C. Stone (2019) Roger Blandford (2020) Victoria Kaspi and Chryssa Kouveliotou (2021) Lennart Lindegren and Michael Perryman (2022) Matthew Bailes, Duncan Lorimer and Maura McLaughlin (2023) Shrinivas R. Kulkarni (2024)
Life science and medicine	Stanley Norman Cohen, Herbert Boyer, Yuet-Wai Kan and Richard Doll (2004) Michael Berridge (2005) Xiaodong Wang (2006) Robert Lefkowitz (2007) Ian Wilmut, Keith H. S. Campbell and Shinya Yamanaka (2008) Douglas Coleman and Jeffrey Friedman (2009) David Julius (2010) Jules Hoffmann, Ruslan Medzhitov and Bruce Beutler (2011) Franz-Ulrich Hartl and Arthur L. Horwich (2012) Jeffrey C. Hall, Michael Rosbash and Michael W. Young (2013) Kazutoshi Mori and Peter Walter (2014) Bonnie Bassler and Everett Peter Greenberg (2015) Adrian Bird and Huda Zoghbi (2016) Ian R. Gibbons and Ronald Vale (2017) Mary-Claire King (2018) Maria Jasin (2019) Gero Miesenböck, Peter Hegemann and Georg Nagel (2020) Scott D. Emr (2021) Paul A. Negulescu and Michael J. Welsh (2022) Patrick Cramer and Eva Nogales (2023) Stuart H. Orkin and Swee Lay Thein (2024)
Mathematical science	Shiing-Shen Chern (2004) Andrew Wiles (2005) David Mumford and Wentsun Wu (2006) Robert Langlands and Richard Taylor (2007) Vladimir Arnold and Ludwig Faddeev (2008) Simon Donaldson and Clifford Taubes (2009) Jean Bourgain (2010) Demetrios Christodoulou and Richard S. Hamilton (2011) Maxim Kontsevich (2012) David Donoho (2013) George Lusztig (2014) Gerd Faltings and Henryk Iwaniec (2015) Nigel Hitchin (2016) János Kollár and Claire Voisin (2017) Luis Caffarelli (2018) Michel Talagrand (2019) Alexander Beilinson and David Kazhdan (2020) Jean-Michel Bismut and Jeff Cheeger (2021) Noga Alon and Ehud Hrushovski (2022) Vladimir Drinfeld and Shing-Tung Yau (2023) Peter Sarnak (2024)

United States National Medal of Science laureates

Behavioral and social science

1960s	1964 Neal Elgar Miller
1980s	1986 Herbert A. Simon 1987 Anne Anastasi George J. Stigler 1988 Milton Friedman
1990s	1990 Leonid Hurwicz Patrick Suppes 1991 George A. Miller 1992 Eleanor J. Gibson 1994 Robert K. Merton 1995 Roger N. Shepard 1996 Paul Samuelson 1997 William K. Estes 1998 William Julius Wilson 1999 Robert M. Solow
2000s	2000 Gary Becker 2003 R. Duncan Luce 2004 Kenneth Arrow 2005 Gordon H. Bower 2008 Michael I. Posner 2009 Mortimer Mishkin
2010s	2011 Anne Treisman 2014 Robert Axelrod 2015 Albert Bandura

Biological sciences

1960s	1963 C. B. van Niel 1964 Theodosius Dobzhansky Marshall W. Nirenberg 1965 Francis P. Rous George G. Simpson Donald D. Van Slyke 1966 Edward F. Knipling Fritz Albert Lipmann William C. Rose Sewall Wright 1967 Kenneth S. Cole Harry F. Harlow Michael Heidelberger Alfred H. Sturtevant 1968 Horace Barker Bernard B. Brodie Detlev W. Bronk Jay Lush Burrhus Frederic Skinner 1969 Robert Huebner Ernst Mayr
1970s	1970 Barbara McClintock Albert B. Sabin 1973 Daniel I. Arnon Earl W. Sutherland Jr. 1974 Britton Chance Erwin Chargaff James V. Neel James Augustine Shannon 1975 Hallowell Davis Paul Gyorgy Sterling B. Hendricks Orville Alvin Vogel 1976 Roger Guillemin Keith Roberts Porter Efraim Racker E. O. Wilson 1979 Robert H. Burris Elizabeth C. Crosby Arthur Kornberg Severo Ochoa Earl Reece Stadtman George Ledyard Stebbins Paul Alfred Weiss
1980s	1981 Philip Handler 1982 Seymour Benzer Glenn W. Burton Mildred Cohn 1983 Howard L. Bachrach Paul Berg Wendell L. Roelofs Berta Scharrer 1986 Stanley Cohen Donald A. Henderson Vernon B. Mountcastle George Emil Palade Joan A. Steitz 1987 Michael E. DeBakey Theodor O. Diener Harry Eagle Har Gobind Khorana Rita Levi-Montalcini 1988 Michael S. Brown Stanley Norman Cohen Joseph L. Goldstein Maurice R. Hilleman Eric R. Kandel Rosalyn Sussman Yalow 1989 Katherine Esau Viktor Hamburger Philip Leder Joshua Lederberg Roger W. Sperry Harland G. Wood
1990s	1990 Baruj Benacerraf Herbert W. Boyer Daniel E. Koshland Jr. Edward B. Lewis David G. Nathan E. Donnall Thomas 1991 Mary Ellen Avery G. Evelyn Hutchinson Elvin A. Kabat Robert W. Kates Salvador Luria Paul A. Marks Folke K. Skoog Paul C. Zamecnik 1992 Maxine Singer Howard Martin Temin 1993 Daniel Nathans Salome G. Waelsch 1994 Thomas Eisner Elizabeth F. Neufeld 1995 Alexander Rich 1996 Ruth Patrick 1997 James Watson Robert A. Weinberg 1998 Bruce Ames Janet Rowley 1999 David Baltimore Jared Diamond Lynn Margulis
2000s	2000 Nancy C. Andreasen Peter H. Raven Carl Woese 2001 Francisco J. Ayala George F. Bass Mario R. Capecchi Ann Graybiel Gene E. Likens Victor A. McKusick Harold Varmus 2002 James E. Darnell Evelyn M. Witkin 2003 J. Michael Bishop Solomon H. Snyder Charles Yanofsky 2004 Norman E. Borlaug Phillip A. Sharp Thomas E. Starzl 2005 Anthony Fauci Torsten N. Wiesel 2006 Rita R. Colwell Nina Fedoroff Lubert Stryer 2007 Robert J. Lefkowitz Bert W. O'Malley 2008 Francis S. Collins Elaine Fuchs J. Craig Venter 2009 Susan L. Lindquist Stanley B. Prusiner
2010s	2010 Ralph L. Brinster Rudolf Jaenisch 2011 Lucy Shapiro Leroy Hood Sallie Chisholm 2012 May Berenbaum Bruce Alberts 2013 Rakesh K. Jain 2014 Stanley Falkow Mary-Claire King Simon Levin

Chemistry

1960s	1964 Roger Adams
1980s	1982 F. Albert Cotton Gilbert Stork 1983 Roald Hoffmann George C. Pimentel Richard N. Zare 1986 Harry B. Gray Yuan Tseh Lee Carl S. Marvel Frank H. Westheimer 1987 William S. Johnson Walter H. Stockmayer Max Tishler 1988 William O. Baker Konrad E. Bloch Elias J. Corey 1989 Richard B. Bernstein Melvin Calvin Rudolph A. Marcus Harden M. McConnell
1990s	1990 Elkan Blout Karl Folkers John D. Roberts 1991 Ronald Breslow Gertrude B. Elion Dudley R. Herschbach Glenn T. Seaborg 1992 Howard E. Simmons Jr. 1993 Donald J. Cram Norman Hackerman 1994 George S. Hammond 1995 Thomas Cech Isabella L. Karle 1996 Norman Davidson 1997 Darleane C. Hoffman Harold S. Johnston 1998 John W. Cahn George M. Whitesides 1999 Stuart A. Rice John Ross Susan Solomon
2000s	2000 John D. Baldeschwieler Ralph F. Hirschmann 2001 Ernest R. Davidson Gábor A. Somorjai 2002 John I. Brauman 2004 Stephen J. Lippard 2005 Tobin J. Marks 2006 Marvin H. Caruthers Peter B. Dervan 2007 Mostafa A. El-Sayed 2008 Joanna Fowler JoAnne Stubbe 2009 Stephen J. Benkovic Marye Anne Fox
2010s	2010 Jacqueline K. Barton Peter J. Stang 2011 Allen J. Bard M. Frederick Hawthorne 2012 Judith P. Klinman Jerrold Meinwald 2013 Geraldine L. Richmond 2014 A. Paul Alivisatos

Engineering sciences

1960s	1962 Theodore von Kármán 1963 Vannevar Bush John Robinson Pierce 1964 Charles S. Draper Othmar H. Ammann 1965 Hugh L. Dryden Clarence L. Johnson Warren K. Lewis 1966 Claude E. Shannon 1967 Edwin H. Land Igor I. Sikorsky 1968 J. Presper Eckert Nathan M. Newmark 1969 Jack St. Clair Kilby
1970s	1970 George E. Mueller 1973 Harold E. Edgerton Richard T. Whitcomb 1974 Rudolf Kompfner Ralph Brazelton Peck Abel Wolman 1975 Manson Benedict William Hayward Pickering Frederick E. Terman Wernher von Braun 1976 Morris Cohen Peter C. Goldmark Erwin Wilhelm Müller 1979 Emmett N. Leith Raymond D. Mindlin Robert N. Noyce Earl R. Parker Simon Ramo
1980s	1982 Edward H. Heinemann Donald L. Katz 1983 Bill Hewlett George Low John G. Trump 1986 Hans Wolfgang Liepmann Tung-Yen Lin Bernard M. Oliver 1987 Robert Byron Bird H. Bolton Seed Ernst Weber 1988 Daniel C. Drucker Willis M. Hawkins George W. Housner 1989 Harry George Drickamer Herbert E. Grier
1990s	1990 Mildred Dresselhaus Nick Holonyak Jr. 1991 George H. Heilmeier Luna B. Leopold H. Guyford Stever 1992 Calvin F. Quate John Roy Whinnery 1993 Alfred Y. Cho 1994 Ray W. Clough 1995 Hermann A. Haus 1996 James L. Flanagan C. Kumar N. Patel 1998 Eli Ruckenstein 1999 Kenneth N. Stevens
2000s	2000 Yuan-Cheng B. Fung 2001 Andreas Acrivos 2002 Leo Beranek 2003 John M. Prausnitz 2004 Edwin N. Lightfoot 2005 Jan D. Achenbach 2006 Robert S. Langer 2007 David J. Wineland 2008 Rudolf E. Kálmán 2009 Amnon Yariv
2010s	2010 Shu Chien 2011 John B. Goodenough 2012 Thomas Kailath

Mathematical, statistical, and computer sciences

1960s	1963 Norbert Wiener 1964 Solomon Lefschetz H. Marston Morse 1965 Oscar Zariski 1966 John Milnor 1967 Paul Cohen 1968 Jerzy Neyman 1969 William Feller
1970s	1970 Richard Brauer 1973 John Tukey 1974 Kurt Gödel 1975 John W. Backus Shiing-Shen Chern George Dantzig 1976 Kurt Otto Friedrichs Hassler Whitney 1979 Joseph L. Doob Donald E. Knuth
1980s	1982 Marshall H. Stone 1983 Herman Goldstine Isadore Singer 1986 Peter Lax Antoni Zygmund 1987 Raoul Bott Michael Freedman 1988 Ralph E. Gomory Joseph B. Keller 1989 Samuel Karlin Saunders Mac Lane Donald C. Spencer
1990s	1990 George F. Carrier Stephen Cole Kleene John McCarthy 1991 Alberto Calderón 1992 Allen Newell 1993 Martin David Kruskal 1994 John Cocke 1995 Louis Nirenberg 1996 Richard Karp Stephen Smale 1997 Shing-Tung Yau 1998 Cathleen Synge Morawetz 1999 Felix Browder Ronald R. Coifman
2000s	2000 John Griggs Thompson Karen Uhlenbeck 2001 Calyampudi R. Rao Elias M. Stein 2002 James G. Glimm 2003 Carl R. de Boor 2004 Dennis P. Sullivan 2005 Bradley Efron 2006 Hyman Bass 2007 Leonard Kleinrock Andrew J. Viterbi 2009 David B. Mumford
2010s	2010 Richard A. Tapia S. R. Srinivasa Varadhan 2011 Solomon W. Golomb Barry Mazur 2012 Alexandre Chorin David Blackwell 2013 Michael Artin

Physical sciences

1960s	1963 Luis W. Alvarez 1964 Julian Schwinger Harold Urey Robert Burns Woodward 1965 John Bardeen Peter Debye Leon M. Lederman William Rubey 1966 Jacob Bjerknes Subrahmanyan Chandrasekhar Henry Eyring John H. Van Vleck Vladimir K. Zworykin 1967 Jesse Beams Francis Birch Gregory Breit Louis Hammett George Kistiakowsky 1968 Paul Bartlett Herbert Friedman Lars Onsager Eugene Wigner 1969 Herbert C. Brown Wolfgang Panofsky
1970s	1970 Robert H. Dicke Allan R. Sandage John C. Slater John A. Wheeler Saul Winstein 1973 Carl Djerassi Maurice Ewing Arie Jan Haagen-Smit Vladimir Haensel Frederick Seitz Robert Rathbun Wilson 1974 Nicolaas Bloembergen Paul Flory William Alfred Fowler Linus Carl Pauling Kenneth Sanborn Pitzer 1975 Hans A. Bethe Joseph O. Hirschfelder Lewis Sarett Edgar Bright Wilson Chien-Shiung Wu 1976 Samuel Goudsmit Herbert S. Gutowsky Frederick Rossini Verner Suomi Henry Taube George Uhlenbeck 1979 Richard P. Feynman Herman Mark Edward M. Purcell John Sinfelt Lyman Spitzer Victor F. Weisskopf
1980s	1982 Philip W. Anderson Yoichiro Nambu Edward Teller Charles H. Townes 1983 E. Margaret Burbidge Maurice Goldhaber Helmut Landsberg Walter Munk Frederick Reines Bruno B. Rossi J. Robert Schrieffer 1986 Solomon J. Buchsbaum H. Richard Crane Herman Feshbach Robert Hofstadter Chen-Ning Yang 1987 Philip Abelson Walter Elsasser Paul C. Lauterbur George Pake James A. Van Allen 1988 D. Allan Bromley Paul Ching-Wu Chu Walter Kohn Norman Foster Ramsey Jr. Jack Steinberger 1989 Arnold O. Beckman Eugene Parker Robert Sharp Henry Stommel
1990s	1990 Allan M. Cormack Edwin M. McMillan Robert Pound Roger Revelle 1991 Arthur L. Schawlow Ed Stone Steven Weinberg 1992 Eugene M. Shoemaker 1993 Val Fitch Vera Rubin 1994 Albert Overhauser Frank Press 1995 Hans Dehmelt Peter Goldreich 1996 Wallace S. Broecker 1997 Marshall Rosenbluth Martin Schwarzschild George Wetherill 1998 Don L. Anderson John N. Bahcall 1999 James Cronin Leo Kadanoff
2000s	2000 Willis E. Lamb Jeremiah P. Ostriker Gilbert F. White 2001 Marvin L. Cohen Raymond Davis Jr. Charles Keeling 2002 Richard Garwin W. Jason Morgan Edward Witten 2003 G. Brent Dalrymple Riccardo Giacconi 2004 Robert N. Clayton 2005 Ralph A. Alpher Lonnie Thompson 2006 Daniel Kleppner 2007 Fay Ajzenberg-Selove Charles P. Slichter 2008 Berni Alder James E. Gunn 2009 Yakir Aharonov Esther M. Conwell Warren M. Washington
2010s	2011 Sidney Drell Sandra Faber Sylvester James Gates 2012 Burton Richter Sean C. Solomon 2014 Shirley Ann Jackson

v t e Laureates of the Nobel Prize in Chemistry
1901–1925	1901: Jacobus van 't Hoff 1902: Emil Fischer 1903: Svante Arrhenius 1904: William Ramsay 1905: Adolf von Baeyer 1906: Henri Moissan 1907: Eduard Buchner 1908: Ernest Rutherford 1909: Wilhelm Ostwald 1910: Otto Wallach 1911: Marie Curie 1912: Victor Grignard / Paul Sabatier 1913: Alfred Werner 1914: Theodore Richards 1915: Richard Willstätter 1916 1917 1918: Fritz Haber 1919 1920: Walther Nernst 1921: Frederick Soddy 1922: Francis Aston 1923: Fritz Pregl 1924 1925: Richard Zsigmondy
1926–1950	1926: Theodor Svedberg 1927: Heinrich Wieland 1928: Adolf Windaus 1929: Arthur Harden / Hans von Euler-Chelpin 1930: Hans Fischer 1931: Carl Bosch / Friedrich Bergius 1932: Irving Langmuir 1933 1934: Harold Urey 1935: Frédéric Joliot-Curie / Irène Joliot-Curie 1936: Peter Debye 1937: Norman Haworth / Paul Karrer 1938: Richard Kuhn 1939: Adolf Butenandt / Leopold Ružička 1940 1941 1942 1943: George de Hevesy 1944: Otto Hahn 1945: Artturi Virtanen 1946: James B. Sumner / John Northrop / Wendell Meredith Stanley 1947: Robert Robinson 1948: Arne Tiselius 1949: William Giauque 1950: Otto Diels / Kurt Alder
1951–1975	1951: Edwin McMillan / Glenn T. Seaborg 1952: Archer Martin / Richard Synge 1953: Hermann Staudinger 1954: Linus Pauling 1955: Vincent du Vigneaud 1956: Cyril Hinshelwood / Nikolay Semyonov 1957: Alexander Todd 1958: Frederick Sanger 1959: Jaroslav Heyrovský 1960: Willard Libby 1961: Melvin Calvin 1962: Max Perutz / John Kendrew 1963: Karl Ziegler / Giulio Natta 1964: Dorothy Hodgkin 1965: Robert Woodward 1966: Robert S. Mulliken 1967: Manfred Eigen / Ronald Norrish / George Porter 1968: Lars Onsager 1969: Derek Barton / Odd Hassel 1970: Luis Federico Leloir 1971: Gerhard Herzberg 1972: Christian B. Anfinsen / Stanford Moore / William Stein 1973: Ernst Otto Fischer / Geoffrey Wilkinson 1974: Paul Flory 1975: John Cornforth / Vladimir Prelog
1976–2000	1976: William Lipscomb 1977: Ilya Prigogine 1978: Peter D. Mitchell 1979: Herbert C. Brown / Georg Wittig 1980: Paul Berg / Walter Gilbert / Frederick Sanger 1981: Kenichi Fukui / Roald Hoffmann 1982: Aaron Klug 1983: Henry Taube 1984: Robert Merrifield 1985: Herbert A. Hauptman / Jerome Karle 1986: Dudley R. Herschbach / Yuan T. Lee / John Polanyi 1987: Donald J. Cram / Jean-Marie Lehn / Charles J. Pedersen 1988: Johann Deisenhofer / Robert Huber / Hartmut Michel 1989: Sidney Altman / Thomas Cech 1990: Elias Corey 1991: Richard R. Ernst 1992: Rudolph A. Marcus 1993: Kary Mullis / Michael Smith 1994: George Olah 1995: Paul J. Crutzen / Mario Molina / F. Sherwood Rowland 1996: Robert Curl / Harold Kroto / Richard Smalley 1997: Paul D. Boyer / John E. Walker / Jens Christian Skou 1998: Walter Kohn / John Pople 1999: Ahmed Zewail 2000: Alan J. Heeger / Alan MacDiarmid / Hideki Shirakawa
2001–present	2001: William Knowles / Ryoji Noyori / K. Barry Sharpless 2002: John B. Fenn / Koichi Tanaka / Kurt Wüthrich 2003: Peter Agre / Roderick MacKinnon 2004: Aaron Ciechanover / Avram Hershko / Irwin Rose 2005: Robert H. Grubbs / Richard R. Schrock / Yves Chauvin 2006: Roger D. Kornberg 2007: Gerhard Ertl 2008: Osamu Shimomura / Martin Chalfie / Roger Y. Tsien 2009: Venkatraman Ramakrishnan / Thomas A. Steitz / Ada E. Yonath 2010: Richard F. Heck / Akira Suzuki / Ei-ichi Negishi 2011: Dan Shechtman 2012: Robert Lefkowitz / Brian Kobilka 2013: Martin Karplus / Michael Levitt / Arieh Warshel 2014: Eric Betzig / Stefan Hell / William E. Moerner 2015: Tomas Lindahl / Paul L. Modrich / Aziz Sancar 2016: Jean-Pierre Sauvage / Fraser Stoddart / Ben Feringa 2017: Jacques Dubochet / Joachim Frank / Richard Henderson 2018: Frances Arnold / Gregory Winter / George Smith 2019: John B. Goodenough / M. Stanley Whittingham / Akira Yoshino 2020: Emmanuelle Charpentier / Jennifer Doudna 2021: David MacMillan / Benjamin List 2022: Carolyn R. Bertozzi / Morten P. Meldal / Karl Barry Sharpless 2023: Moungi G. Bawendi / Louis E. Brus / Alexei I. Ekimov 2024: David Baker / Demis Hassabis / John M. Jumper

v t e 2012 Nobel Prize laureates
Chemistry	Robert Lefkowitz (United States) Brian Kobilka (United States)
Literature (2012)	Mo Yan (China)
Peace (2012)	European Union
Physics	Serge Haroche (France) David J. Wineland (United States)
Physiology or Medicine	John Gurdon (United Kingdom) Shinya Yamanaka (Japan)
Economic Sciences	Alvin E. Roth (United States) Lloyd Shapley (United States)
Nobel Prize recipients 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017

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