Misplaced Pages

Rostafuroxin

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Rostafuroxin
Names
IUPAC name 21,23-Epoxy-24-nor-5β-chola-20,22-diene-3β,14β,17-triol
Systematic IUPAC name (1S,3aS,3bR,5aR,7S,9aS,9bS,11aS)-1-(Furan-3-yl)-9a,11a-dimethylhexadecahydro-3aH-cyclopentaphenanthrene-1,3a,7-triol
Identifiers
CAS Number
3D model (JSmol)
PubChem CID
UNII
CompTox Dashboard (EPA)
SMILES
  • C12CC(C1CC32CC4(3(CC4(C5=COC=C5)O)O)C)O
Properties
Chemical formula C23H34O4
Molar mass 374.521 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

Rostafuroxin is a digitoxigenin analog that has been shown to lower blood pressure in an animal model of hypertension. It modulates the effects of the enzyme Na/K-ATPase, which maintains sodium and potassium ion gradients across plasma membranes. Rostafuroxin is being studied in clinical trials for the treatment of essential hypertension.

References

  1. ^ Ferrari, Patrizia; Ferrandi, Mara; Valentini, Giovanni; Bianchi, Giuseppe (2006). "Rostafuroxin: An ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension". American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 290 (3): R529 – R535. doi:10.1152/ajpregu.00518.2005. PMID 16467500.
  2. Ferrari, Patrizia (2010). "Rostafuroxin: An ouabain-inhibitor counteracting specific forms of hypertension". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1802 (12): 1254–1258. doi:10.1016/j.BBAdis.2010.01.009. PMID 20083196.
  3. "Efficacy of Rostafuroxin in the Treatment of Essential Hypertension". clinicaltrials.gov.
Stub icon

This drug article relating to the cardiovascular system is a stub. You can help Misplaced Pages by expanding it.

Categories: