Rox or ROX may refer to:
- Roseau Municipal Airport (IATA code), airport in Roseau, Minnesota
- Rox (album), an album by California punk band Supernova
- Rox (singer), London-based singer
- Rox (American TV series)
- ROX (Belgian TV series)
- Rox, Nevada, a ghost town
- Roxithromycin, sold under the trade name ROX
- ROX Desktop, a Unix desktop environment based on the ROX-Filer file manager
- Rox Jewellers (retailer), in the United Kingdom
- Brockton Rox, a minor league baseball team in Brockton, Massachusetts
- St. Cloud Rox (minor league baseball), a team in St. Cloud, Minnesota, that played from 1946 to 1971
- St. Cloud Rox (collegiate summer baseball), a team in St. Cloud, Minnesota, since 1997
- The Rox, a renamed Ellis Island in the Wild Cards book series
- "Rox", a song by Scottish band The Aliens from the album Astronomy for Dogs
- The Rox, a nickname for the Colorado Rockies
- The Rox, a nickname for the Houston Rockets
- Rox, a model of bicycle computer made by Sigma Sport
- Rox, the currency in the children's online game Moshi Monsters
- ROX is the ticker symbol and shorthand nomer for Castle Brands
- Rox, a main character in the animated television series Sunny Day
- Rox, a cosmetic outfit in Fortnite Battle Royale
- Rox, a videogame released in 1998 for Sega Saturn and in 2003 for PlayStation
- Roxburghshire, historic county in Scotland, Chapman code
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