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Ru360

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Ru360
Names
IUPAC name azanide;formic acid;ruthenium(5+);trichloride;hydrate
Other names Ru360; (μ)2OCl3; Obftar
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
PubChem CID
InChI
  • InChI=1S/2CH2O2.3ClH.8H3N.O.2Ru/c2*2-1-3;;;;;;;;;;;;;;/h2*1H,(H,2,3);3*1H;8*1H3;;;/q;;;;;;;;;;;;;-2;+3;+4/p-5Key: WQWDSQZHHKHDOS-UHFFFAOYSA-I
SMILES
  • C(=O).C(=O).N.N.N.N.N.N.N.N....
Properties
Chemical formula C2H26Cl3N8O5Ru2
Molar mass 550.77 g·mol
Appearance Reddish brown solid
Solubility in water deoxygenated H2O
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

Ru360 is an oxo-bridged dinuclear ruthenium ammine complex with an absorption spectrum maximum at 360 nm. It is an analog of ruthenium red, a well-known effective inhibitor of the mitochondrial calcium uniporter.

Ru360 was discovered after scientists found that commercial preparations of ruthenium red were often less than 20% pure, and that the crude mixture produced a stronger inhibition than the purified product. This component was later isolated and its structure determined, Ru360 has structural formula (μ-O)2Cl3, that is, an oxygen-linked chain only two octahedral ruthenium–ammine units rather than the three of ruthenium red. One of the ruthenium atoms is in a +3 oxidation state, and the other in a +4 oxidation state. In addition to the four ammonia ligands, each ruthenium also has one formate group and there are a total of three chloride ions to balance the charge. In solution, chloride or hydroxide groups displace the formates.

Since Ru360 inhibits the flow of calcium into mitochondria, which can prevent the opening of the mitochondrial permeability transition pore, it has been investigated as a therapeutic treatment for stroke and heart attack.

References

  1. ^ Ying, W. L.; Emerson, J.; Clarke, M. J.; Sanadi, D. R. (1991-05-21). "Inhibition of mitochondrial calcium ion transport by an oxo-bridged dinuclear ruthenium ammine complex". Biochemistry. 30 (20): 4949–4952. doi:10.1021/bi00234a016. ISSN 0006-2960. PMID 2036363.
  2. Broekemeier, K. M.; Krebsbach, R. J.; Pfeiffer, D. R. (1994-10-12). "Inhibition of the mitochondrial Ca uniporter by pure and impure ruthenium red". Molecular and Cellular Biochemistry. 139 (1): 33–40. doi:10.1007/bf00944201. ISSN 0300-8177. PMID 7531818. S2CID 516473.
  3. García-Rivas, G. de J.; Carvajal, K.; Correa, F.; Zazueta, C. (2006-12-01). "Ru360, a specific mitochondrial calcium uptake inhibitor, improves cardiac post-ischaemic functional recovery in rats in vivo". British Journal of Pharmacology. 149 (7): 829–837. doi:10.1038/sj.bjp.0706932. ISSN 0007-1188. PMC 2014682. PMID 17031386.
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