Rufe may refer to:
People
- Rufus Travis Amis (1912-2007), American entrepreneur
- Rufus Rufe Clarke (1900-1983), American Major League Baseball pitcher
- Rufe Davis (1908-1974), American actor
- James Ruffus Rufe Gentry (1918-1997), American Major League Baseball pitcher
- Henry "Rufe" Johnson (1908-1974), American Piedmont blues guitarist, pianist, singer and songwriter
- Rufe Persful (1906-1991), American criminal
- Wilmer R. Waters (1914-1995), American politician
- Cynthia M. Rufe (born 1948), United States District Court judge
Other uses
- Allied World War II reporting name for the Nakajima A6M2-N Japanese floatplane
- Rufe, Oklahoma, United States, an unincorporated community
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