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Russell A. Brown

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American physician and computer scientist
Russell A. Brown in 2007

Russell A. Brown, an American physician and computer scientist, is the inventor of the N-localizer technology that enables guidance of stereotactic surgery or radiosurgery using medical images that are obtained via computed tomography (CT), magnetic resonance imaging (MRI), or positron emission tomography (PET).

Brown invented the N-localizer in 1978 when he was a medical student investigating image-guided surgery in the laboratory of his mentor, James A. Nelson, at the University of Utah. A few months later, Brown designed and built the first CT-compatible stereotactic frame in order to test the concept of the N-localizer.

Brown also made contributions to the k-d tree and to the generalized Born model of implicit solvation.

References

  1. "System Using Computed Tomography as for Selective Body Treatment". U.S. Patent 4608977. 1986.
  2. Galloway, RL Jr. (2015). "Introduction and Historical Perspectives on Image-Guided Surgery". In Golby, AJ (ed.). Image-Guided Neurosurgery. Amsterdam: Elsevier. pp. 3–4.
  3. Thomas DG, Anderson RE, du Boulay GH (1984). "CT-guided stereotactic neurosurgery: experience in 24 cases with a new stereotactic system". Journal of Neurology, Neurosurgery & Psychiatry. 47 (1): 9–16. doi:10.1136/jnnp.47.1.9. PMC 1027634. PMID 6363629.
  4. Heilbrun MP, Sunderland PM, McDonald PR, Wells TH Jr, Cosman E, Ganz E (1987). "Brown-Roberts-Wells stereotactic frame modifications to accomplish magnetic resonance imaging guidance in three planes". Applied Neurophysiology. 50 (1–6): 143–152. doi:10.1159/000100700. PMID 3329837.
  5. Maciunas RJ, Kessler RM, Maurer C, Mandava V, Watt G, Smith G (1992). "Positron emission tomography imaging-directed stereotactic neurosurgery". Stereotactic and Functional Neurosurgery. 58 (1–4): 134–140. doi:10.1159/000098986. PMID 1439330.
  6. Gildenberg, PL; Krauss, JK (2009). "History of Stereotactic Surgery". In Lozano, AM; Gildenberg, PL; Tasker, RR (eds.). Textbook of Stereotactic and Functional Neurosurgery. Berlin: Springer-Verlag. p. 23.
  7. Mozdy, Michael (2017-08-10). "Inventing the N-Localizer for Stereotactic Neurosurgery: the Story of a Young Researcher in Radiology and Imaging Sciences". Radiology. Retrieved 2024-08-09.
  8. Brown R (2015). "Building a balanced k-d tree in O(kn log n) time". Journal of Computer Graphics Techniques. 4 (1): 50–68.
  9. Brown RA, Case DA (2006). "Second derivatives in generalized Born theory". Journal of Computational Chemistry. 27 (14): 1662–1675. doi:10.1002/jcc.20479. PMID 16900491. S2CID 38418374.
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