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Ryanodine receptor 3

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Transport protein and coding gene in humans
RYR3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4ERV

Identifiers
AliasesRYR3, RYR-3, ryanodine receptor 3
External IDsOMIM: 180903; MGI: 99684; HomoloGene: 68151; GeneCards: RYR3; OMA:RYR3 - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)
Chromosome 15 (human)Genomic location for RYR3Genomic location for RYR3
Band15q13.3-q14Start33,310,962 bp
End33,866,121 bp
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)
Chromosome 2 (mouse)Genomic location for RYR3Genomic location for RYR3
Band2|2 E3- E4Start112,461,700 bp
End113,047,441 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • thoracic diaphragm

  • sural nerve

  • right hemisphere of cerebellum

  • caudate nucleus

  • putamen

  • right uterine tube

  • nucleus accumbens

  • right frontal lobe

  • body of uterus

  • gastrocnemius muscle
Top expressed in
  • olfactory tubercle

  • lateral septal nucleus

  • medial dorsal nucleus

  • subiculum

  • mammillary body

  • nucleus accumbens

  • motor neuron

  • lateral geniculate nucleus

  • globus pallidus

  • substantia nigra
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6263

20192

Ensembl

ENSG00000198838

ENSMUSG00000057378

UniProt

Q15413

A2AGL3

RefSeq (mRNA)

NM_001036
NM_001243996

NM_177652
NM_001319156

RefSeq (protein)

NP_001027
NP_001230925

NP_001306085

Location (UCSC)Chr 15: 33.31 – 33.87 MbChr 2: 112.46 – 113.05 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Ryanodine receptor 3 is one of a class of ryanodine receptors and a protein that in humans is encoded by the RYR3 gene. The protein encoded by this gene is both a calcium channel and a receptor for the plant alkaloid ryanodine. RYR3 and RYR1 control the resting calcium ion concentration in skeletal muscle.

See also

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000198838Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000057378Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Sorrentino V, Giannini G, Malzac P, Mattei MG (Feb 1994). "Localization of a novel ryanodine receptor gene (RYR3) to human chromosome 15q14-q15 by in situ hybridization". Genomics. 18 (1): 163–5. doi:10.1006/geno.1993.1446. PMID 8276408.
  6. Perez CF, López JR, Allen PD (March 2005). "Expression levels of RyR1 and RyR3 control resting free Ca2+ in skeletal muscle". Am. J. Physiol., Cell Physiol. 288 (3): C640–9. doi:10.1152/ajpcell.00407.2004. PMID 15548569. S2CID 30888541.

Further reading

External links

Membrane transport protein: ion channels (TC 1A)
Ca: Calcium channel
Ligand-gated
Voltage-gated
Na: Sodium channel
Constitutively active
Proton-gated
Voltage-gated
K: Potassium channel
Calcium-activated
Inward-rectifier
Tandem pore domain
Voltage-gated
Miscellaneous
Cl: Chloride channel
H: Proton channel
M: CNG cation channel
M: TRP cation channel
H2O (+ solutes): Porin
Cytoplasm: Gap junction
By gating mechanism
Ion channel class
see also disorders


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