S&T can refer to:
- Science and technology, the counterpart of R&D
- Missouri University of Science and Technology, often shortened to "Missouri S&T" or simply "S&T"
- Signalling and Telecommunications or Signalling and Telegraphy in Railway signalling
- S&T Dynamics, machine-tools and auto parts manufacturer of South Korea
- Sky & Telescope, a magazine
- Strategy & Tactics, a magazine
- S&T (company), an IT company from Austria
- S&T Motors, the former name for KR Motors, a motorcycle manufacturer in South Korea
- Switching and terminal railroad
- Sales and Trading
- Sherri and Terri, characters from The Simpsons
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