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SAP130
Identifiers
Aliases	SAP130, Sin3A associated protein 130
External IDs	OMIM: 609697; MGI: 1919782; HomoloGene: 11577; GeneCards: SAP130; OMA:SAP130 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q14.3 Start 127,941,217 bp End 128,028,120 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 B1 Start 31,767,424 bp End 31,856,114 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm left testis right testis secondary oocyte testicle ventricular zone ganglionic eminence stromal cell of endometrium gonad popliteal artery Top expressed in zygote tail of embryo genital tubercle secondary oocyte primary oocyte hand yolk sac otic vesicle otolith organ supraoptic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity histone acetyltransferase activity Cellular component nucleus Sin3-type complex nuclear speck Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79595 269003 Ensembl ENSG00000136715 ENSMUSG00000024260 UniProt Q9H0E3 Q8BIH0 RefSeq (mRNA) NM_001145928 NM_024545 NM_001330299 NM_001330300 NM_001330301 NM_001330302 NM_001330303 NM_172965 NM_001357554 NM_001357555 RefSeq (protein) NP_001139400 NP_001317228 NP_001317229 NP_001317230 NP_001317231 NP_001317232 NP_078821 NP_766553 NP_001344483 NP_001344484 Location (UCSC) Chr 2: 127.94 – 128.03 Mb Chr 18: 31.77 – 31.86 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Histone deacetylase complex subunit SAP130 is an enzyme that in humans is encoded by the SAP130 gene.

Function

SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003).

Interactions

SAP130 has been shown to interact with:

• CSN1S1,
• CUL2,
• Myc,
• SIN3A, and
• Von Hippel–Lindau tumor suppressor and

References

1. ^ GRCh38: Ensembl release 89: ENSG00000136715 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000024260 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
6. ^ Fleischer TC, Yun UJ, Ayer DE (May 2003). "Identification and characterization of three new components of the mSin3A corepressor complex". Molecular and Cellular Biology. 23 (10): 3456–67. doi:10.1128/MCB.23.10.3456-3467.2003. PMC 164750. PMID 12724404.
7. ^ "Entrez Gene: SAP130 Sin3A-associated protein, 130kDa".
8. ^ Menon S, Tsuge T, Dohmae N, Takio K, Wei N (2008). "Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome". BMC Biochemistry. 9: 1. doi:10.1186/1471-2091-9-1. PMC 2265268. PMID 18173839.
9. Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E (May 2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". The Journal of Biological Chemistry. 278 (22): 20405–12. doi:10.1074/jbc.M211795200. PMC 4031917. PMID 12660246.

Further reading

• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

• Genes on human chromosome 2