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SARG database

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Biological database
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The SARG database also known as Structured Antibiotic Resistance Gene database is a collection of antimicrobial resistance genes. The hierarchical structure of the database is clear to be 1) Type: antibiotic type 2) Subtype: genotype 3) Sequence: reference sequence. The SARG database helps in quick survey of antimicrobial resistance genes from environmental samples. The database was initially integrated from ARDB and Comprehensive Antibiotic Resistance Database, followed by hand curation including removing non-ARG sequences, removing redundant sequences and SNP sequences. Other sources include NCBI nr database and published papers.

Online-analysis pipeline

See also

References

  1. Yin, Xiaole; Jiang, Xiao-Tao; Chai, Benli; Li, Liguan; Yang, Ying; Cole, James R; Tiedje, James M; Zhang, Tong (2018-07-01). Wren, Jonathan (ed.). "ARGs-OAP v2.0 with an expanded SARG database and Hidden Markov Models for enhancement characterization and quantification of antibiotic resistance genes in environmental metagenomes". Bioinformatics. 34 (13): 2263–2270. doi:10.1093/bioinformatics/bty053. ISSN 1367-4803. PMID 29408954.
  2. Murray, Aimee K.; Zhang, Lihong; Yin, Xiaole; Zhang, Tong; Buckling, Angus; Snape, Jason; Gaze, William H. (2018-07-24). Goldberg, Joanna B. (ed.). "Novel Insights into Selection for Antibiotic Resistance in Complex Microbial Communities". mBio. 9 (4): e00969–18, /mbio/9/4/mBio.00969–18.atom. doi:10.1128/mBio.00969-18. ISSN 2150-7511. PMC 6058293. PMID 30042197.
  3. Bürgmann, Helmut; Frigon, Dominic; H Gaze, William; M Manaia, Célia; Pruden, Amy; Singer, Andrew C.; F Smets, Barth; Zhang, Tong (2018-09-01). "Water and sanitation: an essential battlefront in the war on antimicrobial resistance". FEMS Microbiology Ecology. 94 (9). doi:10.1093/femsec/fiy101. ISSN 0168-6496. PMID 29878227.
  4. Yang, Ying; Jiang, Xiaotao; Chai, Benli; Ma, Liping; Li, Bing; Zhang, Anni; Cole, James R.; Tiedje, James M.; Zhang, Tong (2016-08-01). "ARGs-OAP: online analysis pipeline for antibiotic resistance genes detection from metagenomic data using an integrated structured ARG-database". Bioinformatics. 32 (15): 2346–2351. doi:10.1093/bioinformatics/btw136. ISSN 1367-4803. PMID 27153579.
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