SC1 or SC-1 may refer to:
- South Carolina's 1st congressional district
- USS SC-1, a United States Navy submarine chaser commissioned in 1917 and sold in 1921
- SC-01 speech synthesizer by Votrax
- SC01, a FIPS 10-4 region code, see List of FIPS region codes (S–U)
- SC-01, a subdivision code for the Seychelles, see ISO 3166-2:SC
Video games
- The first title in the StarCraft series.
- The first title in the SimCity series
- The first title in the Tom Clancy's Splinter Cell series
Aircraft
- Signal Corps Dirigible No. 1 A 1908 Dirigible built by Thomas Scott Baldwin
- Curtiss SC-1 Seahawk, a version of the American Curtiss SC Seahawk seaplane
- Martin SC-1, a version of the American Curtiss CS reconnaissance and torpedo bomber aircraft
- Short SC.1, the first British fixed-wing vertical take-off and landing (VTOL) aircraft
- Southern Cross Aviation SC-1, an Australian civil aircraft
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