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SCEL
Identifiers
Aliases	SCEL, sciellin
External IDs	OMIM: 604112; MGI: 1891228; HomoloGene: 2850; GeneCards: SCEL; OMA:SCEL - orthologs
Gene location (Human) Chr. Chromosome 13 (human) Band 13q22.3 Start 77,535,674 bp End 77,645,263 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 E2.3 Start 103,750,778 bp End 103,850,233 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh oral cavity skin of arm mucosa of pharynx skin of hip skin of abdomen buccal mucosa cell amniotic fluid gums human penis Top expressed in conjunctival fornix skin of external ear corneal stroma esophagus hair follicle skin of back skin of abdomen epithelium of lens right lung lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding Cellular component cytoplasm extracellular exosome membrane cornified envelope perinuclear region of cytoplasm Biological process embryo development epidermis development keratinocyte differentiation response to mechanical stimulus positive regulation of canonical Wnt signaling pathway embryo development ending in birth or egg hatching Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8796 64929 Ensembl ENSG00000136155 ENSMUSG00000022123 UniProt O95171 Q9EQG3 RefSeq (mRNA) NM_001160706 NM_003843 NM_144777 NM_022886 RefSeq (protein) NP_001154178 NP_003834 NP_659001 NP_075024 Location (UCSC) Chr 13: 77.54 – 77.65 Mb Chr 14: 103.75 – 103.85 Mb PubMed search
Wikidata
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Sciellin is a protein that in humans is encoded by the SCEL gene.

The protein encoded by this gene is a precursor to the cornified envelope of terminally differentiated keratinocytes. This protein localizes to the periphery of cells and may function in the assembly or regulation of proteins in the cornified envelope. Transcript variants encoding different isoforms exist. A transcript variant utilizing an alternative polyA signal has been described in the literature, but its full-length nature has not been determined.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000136155 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000022123 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Champliaud MF, Burgeson RE, Jin W, Baden HP, Olson PF (Dec 1998). "cDNA cloning and characterization of sciellin, a LIM domain protein of the keratinocyte cornified envelope". J Biol Chem. 273 (47): 31547–54. doi:10.1074/jbc.273.47.31547. PMID 9813070.
6. ^ "Entrez Gene: SCEL sciellin".

Further reading

• Corona W, Karkera DJ, Patterson RH, et al. (2004). "Analysis of Sciellin (SCEL) as a candidate gene in esophageal squamous cell carcinoma". Anticancer Res. 24 (3a): 1417–9. PMID 15274303.
• Champliaud MF, Viel A, Baden HP (2003). "The expression of vitamin D-upregulated protein 1 in skin and its interaction with sciellin in cultured keratinocytes". J. Invest. Dermatol. 121 (4): 781–5. doi:10.1046/j.1523-1747.2003.12539.x. PMID 14632196.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Champliaud MF, Baden HP, Koch M, et al. (2001). "Gene characterization of sciellin (SCEL) and protein localization in vertebrate epithelia displaying barrier properties". Genomics. 70 (2): 264–8. doi:10.1006/geno.2000.6390. PMID 11112355.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Kvedar JC, Manabe M, Phillips SB, et al. (1992). "Characterization of sciellin, a precursor to the cornified envelope of human keratinocytes". Differentiation. 49 (3): 195–204. doi:10.1111/j.1432-0436.1992.tb00667.x. PMID 1377656.

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