SDE can stand for:
In science, medicine, and technology
- Screen door effect, a video display issue
- Sebacoyl dinalbuphine ester, an analgesic
- Semantic dictionary encoding
- Software development engineer
- Software development environment
- Spatial Database Engine (ArcSDE)
- Spectral density estimation
- Stochastic differential equation
- sub-divisional error, a read head error mechanism
- System development environment
In politics
- Social Democratic Party (Estonia)
- State delegate equivalents, a part of the Iowa caucuses § Democratic Party
In transportation
- The IATA code for Vicecomodoro Ángel de la Paz Aragonés Airport, an airport in Argentina
- Senai–Desaru Expressway, an expressway in Johor, Malaysia
- Shadwell railway station, a railway station in London, England
Other uses
- S.D.E., a 2000 album by Cam'ron
- Self Defined Ethnicity, an ethnic classification code used by the British government and police
- Self-directed education, self-learning, often synonymous with unschooling
- Strong-side defensive end, a position in American football
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