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SEC22B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NUP, 2NUT, 3EGD, 3EGX
Identifiers
Aliases	SEC22B, ERS-24, SEC22L1, SEC22 homolog B, vesicle trafficking protein (gene/pseudogene), SEC22 homolog B, vesicle trafficking protein
External IDs	OMIM: 604029; MGI: 1338759; HomoloGene: 3597; GeneCards: SEC22B; OMA:SEC22B - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p12 Start 120,150,898 bp End 120,176,520 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F2.2 Start 97,808,506 bp End 97,830,592 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon body of pancreas islet of Langerhans stromal cell of endometrium anterior pituitary epithelium of colon rectum monocyte left adrenal gland Descending thoracic aorta Top expressed in cumulus cell endocardial cushion neural layer of retina yolk sac molar lacrimal gland islet of Langerhans calvaria primitive streak seminal vesicula More reference expression data BioGPS n/a
Gene ontology Molecular function SNAP receptor activity protein binding syntaxin binding SNARE binding Cellular component integral component of membrane Golgi apparatus endoplasmic reticulum membrane membrane melanosome endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment SNARE complex Golgi membrane transport vesicle phagocytic vesicle membrane ER to Golgi transport vesicle membrane synaptic vesicle Biological process positive regulation of protein catabolic process vesicle fusion with Golgi apparatus COPII vesicle coating protein transport vesicle-mediated transport exocytosis retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent endoplasmic reticulum to Golgi vesicle-mediated transport vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane negative regulation of autophagosome assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9554 20333 Ensembl ENSG00000265808 ENSMUSG00000027879 UniProt O75396 O08547 RefSeq (mRNA) NM_004892 NM_011342 RefSeq (protein) NP_004883 NP_035472 Location (UCSC) Chr 1: 120.15 – 120.18 Mb Chr 3: 97.81 – 97.83 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Vesicle-trafficking protein SEC22b is a protein that in humans is encoded by the SEC22B gene.

Function

The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It associates with other SNARE proteins to form a SNARE complex and it is thought to play a role in the ER-Golgi protein trafficking. It is required for platelet alpha-granule biogenesis in megakaryocytes and is essential for the elongated morphology of endothelial cell Weibel-Palade bodies. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins. There is evidence for use of multiple polyadenylation sites for the transcript. SEC22B has been shown to interact with syntaxin 18 and syntaxin 5.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000265808 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000027879 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hay JC, Chao DS, Kuo CS, Scheller RH (April 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell. 89 (1): 149–58. doi:10.1016/S0092-8674(00)80191-9. PMID 9094723. S2CID 8682509.
6. Okumura AJ, Hatsuzawa K, Tamura T, Nagaya H, Saeki K, Okumura F, Nagao K, Nishikawa M, Yoshimura A, Wada I (February 2006). "Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system". The Journal of Biological Chemistry. 281 (7): 4495–506. doi:10.1074/jbc.M509715200. PMID 16354670.
7. ^ "Entrez Gene: SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae)".
8. Lo, Richard W.; Li, Ling; Pluthero, Fred G.; Leung, Richard; Eto, Koji; Kahr, Walter H. A. (2020-08-06). "The endoplasmic reticulum protein SEC22B interacts with NBEAL2 and is required for megakaryocyte α-granule biogenesis". Blood. 136 (6): 715–725. doi:10.1182/blood.2019004276. ISSN 0006-4971.
9. Ellie Karampini; Petra E. Bürgisser; Jenny Olins; Aat A. Mulder; Carolina R. Jost; Dirk Geerts; Jan Voorberg; Ruben Bierings (2020-03-26). "Sec22b determines Weibel-Palade body length by controlling anterograde ER-Golgi transport". Haematologica. 106 (4): 1138–1147. doi:10.3324/haematol.2019.242727. ISSN 1592-8721. PMC 8018124. PMID 32336681.
10. Hatsuzawa, Kiyotaka; Hirose, Hidenori; Tani, Katsuko; Yamamoto, Akitsugu; Scheller, Richard H.; Tagaya, Mitsuo (May 2000). "Syntaxin 18, a SNAP Receptor That Functions in the Endoplasmic Reticulum, Intermediate Compartment, and cis-Golgi Vesicle Trafficking". Journal of Biological Chemistry. 275 (18): 13713–13720. doi:10.1074/jbc.275.18.13713. ISSN 0021-9258. PMID 10788491.
11. Kat, Marije; Karampini, Ellie; Hoogendijk, Arie J.; Bürgisser, Petra E.; Mulder, Aat A.; Alphen, Floris P. J. van; Olins, Jenny; Geerts, Dirk; Biggelaar, Maartje van den; Margadant, Coert; Voorberg, Jan; Bierings, Ruben (2022-01-27). "Syntaxin 5 determines Weibel-Palade body size and von Willebrand factor secretion by controlling Golgi architecture". Haematologica. 107 (8): 1827–1839. doi:10.3324/haematol.2021.280121. ISSN 1592-8721. PMC 9335113. PMID 35081689.

Further reading

• Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, Huang H, Canfield VA, Cheng KC, Yang F, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF (November 2006). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". Journal of Proteome Research. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
• Breuza L, Halbeisen R, Jenö P, Otte S, Barlowe C, Hong W, Hauri HP (November 2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". The Journal of Biological Chemistry. 279 (45): 47242–53. doi:10.1074/jbc.M406644200. PMID 15308636.
• Nakajima K, Hirose H, Taniguchi M, Kurashina H, Arasaki K, Nagahama M, Tani K, Yamamoto A, Tagaya M (August 2004). "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion". The EMBO Journal. 23 (16): 3216–26. doi:10.1038/sj.emboj.7600333. PMC 514507. PMID 15272311.
• Fu GK, Wang JT, Yang J, Au-Young J, Stuve LL (July 2004). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics. 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
• Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, Tani K, Yamamoto A, Tohyama M, Tagaya M (March 2004). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". The EMBO Journal. 23 (6): 1267–78. doi:10.1038/sj.emboj.7600135. PMC 381410. PMID 15029241.
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Xu D, Joglekar AP, Williams AL, Hay JC (December 2000). "Subunit structure of a mammalian ER/Golgi SNARE complex". The Journal of Biological Chemistry. 275 (50): 39631–9. doi:10.1074/jbc.M007684200. PMID 11035026.
• Parlati F, McNew JA, Fukuda R, Miller R, Söllner TH, Rothman JE (September 2000). "Topological restriction of SNARE-dependent membrane fusion". Nature. 407 (6801): 194–8. Bibcode:2000Natur.407..194P. doi:10.1038/35025076. PMID 11001058. S2CID 4410803.
• Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (July 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.

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