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SEC23IP

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Protein-coding gene in the species Homo sapiens
SEC23IP
Identifiers
AliasesSEC23IP, P125, P125A, MSTP053, SEC23 interacting protein, iPLA1beta
External IDsOMIM: 617852; MGI: 2450915; HomoloGene: 38288; GeneCards: SEC23IP; OMA:SEC23IP - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)
Chromosome 10 (human)Genomic location for SEC23IPGenomic location for SEC23IP
Band10q26.11-q26.12Start119,892,730 bp
End119,944,657 bp
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)
Chromosome 7 (mouse)Genomic location for SEC23IPGenomic location for SEC23IP
Band7 F3|7 70.51 cMStart128,346,667 bp
End128,386,560 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • epithelium of colon

  • stromal cell of endometrium

  • secondary oocyte

  • Achilles tendon

  • islet of Langerhans

  • monocyte

  • smooth muscle tissue

  • mucosa of sigmoid colon

  • ventricular zone

  • cartilage tissue
Top expressed in
  • spermatid

  • seminiferous tubule

  • spermatocyte

  • primary oocyte

  • calvaria

  • vestibular membrane of cochlear duct

  • cumulus cell

  • yolk sac

  • endothelial cell of lymphatic vessel

  • gastrula
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11196

207352

Ensembl

ENSG00000107651

ENSMUSG00000055319

UniProt

Q9Y6Y8

Q6NZC7

RefSeq (mRNA)

NM_007190

NM_001029982

RefSeq (protein)

NP_009121

n/a

Location (UCSC)Chr 10: 119.89 – 119.94 MbChr 7: 128.35 – 128.39 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

SEC23-interacting protein is a protein that in humans is encoded by the SEC23IP gene.

COPII-coated vesicles are involved in protein transport from the Endoplasmic Reticulum to the Golgi Apparatus. The protein encoded by this gene was identified by its interaction with a mouse protein similar to yeast Sec23p, an essential component of the COPII. This protein shares significant similarity with phospholipid-modifying proteins, especially phosphatidic acid preferring-phospholipase A1. Overexpression of this protein has been shown to cause disorganization of the endoplasmic reticulum-Golgi intermediate compartment and Golgi apparatus, which suggests its role in the early secretory pathway.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000107651Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000055319Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tani K, Mizoguchi T, Iwamatsu A, Hatsuzawa K, Tagaya M (Aug 1999). "p125 is a novel mammalian Sec23p-interacting protein with structural similarity to phospholipid-modifying proteins". J Biol Chem. 274 (29): 20505–12. doi:10.1074/jbc.274.29.20505. PMID 10400679.
  6. ^ "Entrez Gene: SEC23IP SEC23 interacting protein".

Further reading


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