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SEMA4A

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Protein-coding gene in the species Homo sapiens

SEMA4A
Identifiers
AliasesSEMA4A, CORD10, RP35, SEMAB, SEMB, semaphorin 4A
External IDsOMIM: 607292; MGI: 107560; HomoloGene: 8425; GeneCards: SEMA4A; OMA:SEMA4A - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)
Chromosome 1 (human)Genomic location for SEMA4AGenomic location for SEMA4A
Band1q22Start156,147,366 bp
End156,177,752 bp
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)
Chromosome 3 (mouse)Genomic location for SEMA4AGenomic location for SEMA4A
Band3|3 F1Start88,343,266 bp
End88,368,489 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • granulocyte

  • bone marrow cells

  • blood

  • Amygdala

  • nucleus accumbens

  • skin of abdomen

  • left lobe of thyroid gland

  • retinal pigment epithelium

  • cingulate gyrus
Top expressed in
  • granulocyte

  • Paneth cell

  • retinal pigment epithelium

  • ventromedial nucleus

  • jejunum

  • paraventricular nucleus of hypothalamus

  • arcuate nucleus

  • prostate

  • ileum

  • duodenum
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64218

20351

Ensembl

ENSG00000196189

ENSMUSG00000028064

UniProt

Q9H3S1

Q62178

RefSeq (mRNA)
NM_001193300
NM_001193301
NM_001193302
NM_022367
NM_001370567

NM_001370568
NM_001370569
NM_001370571

NM_001163489
NM_001163490
NM_001163491
NM_013658

RefSeq (protein)
NP_001180229
NP_001180230
NP_001180231
NP_071762
NP_001357496

NP_001357497
NP_001357498
NP_001357500

NP_001156961
NP_001156962
NP_001156963
NP_038686

Location (UCSC)Chr 1: 156.15 – 156.18 MbChr 3: 88.34 – 88.37 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Semaphorin-4A is a protein that in humans is encoded by the SEMA4A gene.

Function

SEMA4A is a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in guidance of axonal migration during neuronal development and in immune responses.

Clinical significance

A germline variant in SEMA4A (V78M) has been demonstrated to confer risk for colorectal cancer type X.

Recently it has been identified as a novel therapeutic target in Multiple myeloma.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000196189Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000028064Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Püschel AW, Adams RH, Betz H (May 1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron. 14 (5): 941–948. doi:10.1016/0896-6273(95)90332-1. PMID 7748561.
  6. ^ "Entrez Gene: SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A".
  7. Schulz E, Klampfl P, Holzapfel S, Janecke AR, Ulz P, Renner W, et al. (October 2014). "Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X". Nature Communications. 5: 5191. Bibcode:2014NatCo...5.5191S. doi:10.1038/ncomms6191. PMC 4214414. PMID 25307848.
  8. Anderson GS, Ballester-Beltran J, Giotopoulos G, Guerrero JA, Surget S, Williamson JC, et al. (April 2022). "Unbiased cell surface proteomics identifies SEMA4A as an effective immunotherapy target for myeloma". Blood. 139 (16): 2471–2482. doi:10.1182/blood.2021015161. PMC 11022854. PMID 35134130.

Further reading

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