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SEPTIN1

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Protein-coding gene in the species Homo sapiens

SEPTIN1
Identifiers
AliasesSEPTIN1, DIFF6, LARP, PNUTL3, SEP1, septin 1, SEPT1
External IDsOMIM: 612897; MGI: 1858916; HomoloGene: 23009; GeneCards: SEPTIN1; OMA:SEPTIN1 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)
Chromosome 16 (human)Genomic location for SEPTIN1Genomic location for SEPTIN1
Band16p11.2Start30,378,135 bp
End30,395,991 bp
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)
Chromosome 7 (mouse)Genomic location for SEPTIN1Genomic location for SEPTIN1
Band7|7 F3Start126,813,619 bp
End126,832,302 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • appendix

  • spleen

  • lymph node

  • thymus

  • blood

  • bone marrow cells

  • mucosa of transverse colon

  • rectum

  • sural nerve
Top expressed in
  • granulocyte

  • thymus

  • ventricular zone

  • blood

  • blastocyst

  • morula

  • spleen

  • neural layer of retina

  • lymph node

  • genital tubercle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1731

54204

Ensembl

ENSG00000180096

ENSMUSG00000000486

UniProt

Q8WYJ6

P42209

RefSeq (mRNA)

NM_052838
NM_001365977

NM_017461

RefSeq (protein)

NP_443070
NP_001352906

NP_059489

Location (UCSC)Chr 16: 30.38 – 30.4 MbChr 7: 126.81 – 126.83 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Septin-1 is a protein that in humans is encoded by the SEPTIN1 gene. It was renamed from SEPT1 to avoid problems where Microsoft Excel would auto-correct the gene name to the date September 1.

Function

This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. This gene encodes a protein associated with the tau-based paired helical filament core, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000180096Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000000486Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Mori T, Miura K, Fujiwara T, Shin S, Inazawa J, Nakamura Y (Sep 1996). "Isolation and mapping of a human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse Diff6". Cytogenetics and Cell Genetics. 73 (3): 224–7. doi:10.1159/000134343. PMID 8697812.
  6. ^ "Entrez Gene: SEPT1 septin 1".
  7. Vincent J (6 August 2020). "Scientists rename human genes to stop Microsoft Excel from misreading them as dates". the Verge. Retrieved 2022-10-24.

Further reading

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