SFE may refer to:
- Sales force effectiveness
- San Fernando Airport (Philippines) IATA code
- Scottish Financial Enterprise, trade body for the financial services sector in Scotland
- Scouts for Equality, advocates for scouts and leaders in the Boy Scouts of America
- Secure function evaluation, in cryptography
- Sigma Phi Epsilon
- Shannon-Fano-Elias coding, a lossless data compression algorithm
- Society of Fuse Engineers, designers of certain automotive fuses
- Solar flare effect
- SparkFun Electronics
- Spec Files Extra, a way to build common packages for OpenSolaris or OpenIndiana
- Stacking-fault energy
- Supercritical fluid extraction
- Supplier-furnished equipment
- Surface free energy, often referred to as Surface energy
- Sydney Futures Exchange, now merged with the Australian Stock Exchange to become the Australian Securities Exchange
- The Encyclopedia of Science Fiction
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