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SL2 RNA

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SL2 RNA
Predicted secondary structure and sequence conservation of SL2
Identifiers
SymbolSL2
RfamRF00199
Other data
RNA typeGene
Domain(s)Eukaryota
GOGO:0000365
SOSO:0000233
PDB structuresPDBe

SL2 RNA is a non-coding RNA involved in trans splicing in lower eukaryotes. Trans-splicing is a form of RNA processing. The acquisition of a spliced leader from an SL RNA is an inter-molecular reaction which precisely joins exons derived from separately transcribed RNAs. Approximately 25% of C. elegans genes are organised into polycistronic transcription units and the presence of SL2 on an mRNA is an indication the gene is in an operon.

References

  1. Dassanayake RS, Chandrasekharan NV, Karunanayake EH (May 2001). "Trans-spliced leader RNA, 5S-rRNA genes and novel variant orphan spliced-leader of the lymphatic filarial nematode Wuchereria bancrofti, and a sensitive polymerase chain reaction based detection assay". Gene. 269 (1–2): 185–193. doi:10.1016/S0378-1119(01)00438-3. PMID 11376950.
  2. Evans D, Blumenthal T (September 2000). "trans splicing of polycistronic Caenorhabditis elegans pre-mRNAs: analysis of the SL2 RNA". Molecular and Cellular Biology. 20 (18): 6659–6667. doi:10.1128/MCB.20.18.6659-6667.2000. PMC 86170. PMID 10958663.

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