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SMPD4

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Protein-coding gene in the species Homo sapiens
SMPD4
Identifiers
AliasesSMPD4, NET13, NSMASE-3, NSMASE3, sphingomyelin phosphodiesterase 4, SKNY, NEDMABA, NEDMEBA
External IDsOMIM: 610457; MGI: 1924876; HomoloGene: 9813; GeneCards: SMPD4; OMA:SMPD4 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)
Chromosome 2 (human)Genomic location for SMPD4Genomic location for SMPD4
Band2q21.1Start130,151,392 bp
End130,182,750 bp
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)
Chromosome 16 (mouse)Genomic location for SMPD4Genomic location for SMPD4
Band16|16 A3Start17,437,218 bp
End17,462,692 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Pituitary Gland

  • anterior pituitary

  • right hemisphere of cerebellum

  • left lobe of thyroid gland

  • canal of the cervix

  • right lobe of thyroid gland

  • apex of heart

  • body of uterus

  • right uterine tube

  • left ovary
Top expressed in
  • tail of embryo

  • otic vesicle

  • genital tubercle

  • otic placode

  • saccule

  • epiblast

  • spermatocyte

  • primary visual cortex

  • superior frontal gyrus

  • ventricular zone
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55627

77626

Ensembl

ENSG00000136699

ENSMUSG00000005899

UniProt

Q9NXE4

Q6ZPR5

RefSeq (mRNA)

NM_001171083
NM_001171084
NM_017751
NM_017951

NM_001164609
NM_001164610
NM_001164611
NM_029945

RefSeq (protein)

NP_001164554
NP_060221
NP_060421
NP_060421.2

NP_001158081
NP_001158082
NP_001158083
NP_084221

Location (UCSC)Chr 2: 130.15 – 130.18 MbChr 16: 17.44 – 17.46 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Sphingomyelin phosphodiesterase 4 is an enzyme that in humans is encoded by the SMPD4 gene.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000136699Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000005899Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Krut O, Wiegmann K, Kashkar H, Yazdanpanah B, Krönke M (May 2006). "Novel tumor necrosis factor-responsive mammalian neutral sphingomyelinase-3 is a C-tail-anchored protein". The Journal of Biological Chemistry. 281 (19): 13784–93. doi:10.1074/jbc.M511306200. PMID 16517606.
  6. "Entrez Gene: SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)".

Further reading

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