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SORBS3

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Protein-coding gene in the species Homo sapiens
SORBS3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2CT3, 2DLM, 2NWM, 2YUP

Identifiers
AliasesSORBS3, SCAM-1, SCAM1, SH3D4, sorbin and SH3 domain containing 3
External IDsOMIM: 610795; MGI: 700013; HomoloGene: 4218; GeneCards: SORBS3; OMA:SORBS3 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)
Chromosome 8 (human)Genomic location for SORBS3Genomic location for SORBS3
Band8p21.3Start22,544,986 bp
End22,575,788 bp
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)
Chromosome 14 (mouse)Genomic location for SORBS3Genomic location for SORBS3
Band14 D2|14 36.27 cMStart70,417,917 bp
End70,449,438 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right testis

  • left testis

  • right coronary artery

  • popliteal artery

  • tibial arteries

  • tibial nerve

  • gastric mucosa

  • left coronary artery

  • canal of the cervix

  • ascending aorta
Top expressed in
  • external carotid artery

  • muscle of thigh

  • internal carotid artery

  • genital tubercle

  • retinal pigment epithelium

  • vestibular membrane of cochlear duct

  • ankle

  • right lung

  • right lung lobe

  • choroid plexus of fourth ventricle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10174

20410

Ensembl

ENSG00000120896

ENSMUSG00000022091

UniProt

O60504

Q9R1Z8

RefSeq (mRNA)

NM_001018003
NM_005775

NM_001271407
NM_001271408
NM_001271409
NM_011366

RefSeq (protein)

NP_001018003
NP_005766

NP_001258336
NP_001258337
NP_001258338
NP_035496

Location (UCSC)Chr 8: 22.54 – 22.58 MbChr 14: 70.42 – 70.45 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Vinexin is a protein that in humans is encoded by the SORBS3 gene.


Interactions

SORBS3 has been shown to interact with DLG5 and MAPK1.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000120896Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000022091Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kioka N, Sakata S, Kawauchi T, Amachi T, Akiyama SK, Okazaki K, Yaen C, Yamada KM, Aota S (Mar 1999). "Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization". J Cell Biol. 144 (1): 59–69. doi:10.1083/jcb.144.1.59. PMC 2148117. PMID 9885244.
  6. Kioka N (Jan 2003). "". Seikagaku. 74 (11): 1356–60. PMID 12510380.
  7. "Entrez Gene: SORBS3 sorbin and SH3 domain containing 3".
  8. Wakabayashi M, Ito Takuya, Mitsushima Masaru, Aizawa Sanae, Ueda Kazumitsu, Amachi Teruo, Kioka Noriyuki (Jun 2003). "Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact". J. Biol. Chem. 278 (24): 21709–14. doi:10.1074/jbc.M211004200. ISSN 0021-9258. PMID 12657639.
  9. Mitsushima M, Suwa Akira, Amachi Teruo, Ueda Kazumitsu, Kioka Noriyuki (Aug 2004). "Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin". J. Biol. Chem. 279 (33): 34570–7. doi:10.1074/jbc.M402304200. ISSN 0021-9258. PMID 15184391.

Further reading

External links

PDB gallery
  • 2ct3: Solution Structure of the SH3 domain of the Vinexin protein 2ct3: Solution Structure of the SH3 domain of the Vinexin protein
  • 2dlm: Solution structure of the first SH3 domain of human vinexin 2dlm: Solution structure of the first SH3 domain of human vinexin
  • 2nwm: Solution structure of the first SH3 domain of human Vinexin and its interaction with the peptides from Vinculin 2nwm: Solution structure of the first SH3 domain of human Vinexin and its interaction with the peptides from Vinculin


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